Tesis

Proporsi Penyakit Paru Interstisial pada Sklerosis Sistemik dan Faktor – faktor yang Berhubungan = Proportion of Interstitial Lung Disease in Systemic Sclerosis and Its Associated Factors.

Latar belakang: Sklerosis sistemik (SSc) merupakan penyakit jaringan ikat sistemik yang sering kali disertai keterlibatan paru, terutama berupa penyakit paru interstisial (ILD). ILD merupakan salah satu penyebab utama morbiditas dan mortalitas pada pasien SSc, namun data mengenai proporsi dan faktor-faktor yang berhubungan dengan ILD pada SSc di Indonesia masih terbatas. Tujuan: Mengetahui proporsi ILD pada pasien sklerosis sistemik serta menganalisis faktorfaktor yang berhubungan dengan kejadian ILD pada pasien tersebut. Metode: Penelitian ini menggunakan desain potong lintang berbasis data sekunder dari rekam medis pasien SSc yang menjalani pemeriksaan HRCT toraks di RSCM antara Januari 2020 hingga Oktober 2024. Total 111 pasien yang memenuhi kriteria inklusi dan eksklusi dianalisis. Data dianalisis secara bivariat dan multivariat menggunakan uji chi-square dan regresi logistik bertahap mundur. Hasil: Pada penelitian ini, rerata usia berkisar 44 tahun (+ 12.05). Proporsi pasien perempuan dengan sklerosis sistemik lebih banyak dibandingkan laki-laki (95.5%). Proporsi SSc-ILD sebesar 55.9% (95% IK: 46.2–65.2%). Analisis multivariat mengidentifikasi bahwa usia >37 tahun, (OR 2,83; 95% IK 1,09–7,34; p=0,032), durasi penyakit >11 bulan (OR 4,01; 95% IK 1,19–13,43; p=0,024), dan kadar laju endap darah (LED) >33,5 mm/jam (OR 4,37; 95% IK 1,84–10,38; p=0,001) berhubungan secara independen dengan kejadian SSc-ILD Kesimpulan: Proporsi SSc-ILD 55,9%, dengan usia >37 tahun, durasi penyakit >11 bulan, dan kadar LED >33.5 mm/jam pada penelitian ini adalah berhubungan secara independen dengan kejadian SSc-ILD .
Kata Kunci: Durasi Penyakit, Kadar LED, SSc-ILD, Usia


Background: Systemic sclerosis (SSc) is a connective tissue disease often involving the lungs, particularly in the form of interstitial lung disease (ILD). ILD is a major cause of morbidity and mortality in SSc patients, but data regarding its proportion and associated factors in Indonesia remain limited. Objective: To determine the proportion of ILD in systemic sclerosis patients and to analyze the factors associated with its occurrence Method: This cross-sectional study used secondary data from medical records of SSc patients who underwent HRCT scans at RSCM between January 2020 and October 2024. A total of 111 eligible patients were included. Data were analyzed using bivariate and multivariate methods, including chi-square and backward stepwise logistic regression tests. Results: In this study, the mean age was 44 years (±12.05). The proportion of female patients with systemic sclerosis was significantly higher than males (95.5%). The proportion of SScILD was 55.9% (95% CI: 46.2–65.2%). Multivariate analysis identified that age >37 years (OR 2.83; 95% CI: 1.09–7.34; p=0.032), disease duration >11 months (OR 4.01; 95% CI: 1.19–13.43; p=0.024), and erythrocyte sedimentation rate (ESR) level >33.5 mm/hour (OR 4.37; 95% CI: 1.84–10.38; p=0.001) were independently associated with the occurrence of SSc-ILD. Conclusion: The proportion of SSc-ILD was 55.9%. Age >37 years, disease duration >11 months, and ESR level >33.5 mm/hour in this research were independently associated with the occurrence of SSc-ILD.
Keywords: Age, Disease Duration, ESR, SSc-ILD