Skripsi

Analisis Hubungan Riwayat Keluarga dengan Karakteristik Klinis Pasien Kanker Paru di RSUP Persahabatan = Analysis of Family History Association with Clinical Characteristics of Lung Cancer Patients at Persahabatan National Respiratory Referral Hospital.

Kanker paru merupakan penyebab utama kematian akibat kanker di Indonesia, dan riwayat keluarga sering dianggap sebagai faktor risiko genetik, meskipun bukti ilmiah masih bervariasi. Penelitian observasional analitik dengan desain potong lintang ini bertujuan menganalisis hubungan antara riwayat keluarga dengan karakteristik klinis pasien kanker paru di RSUP Persahabatan. Data dikumpulkan dari 60 pasien pada periode Maret–Agustus 2025 melalui kuesioner dan rekam medis, mencakup riwayat keluarga kanker, stadium, serta jenis kanker paru. Mayoritas pasien berusia 45–59 tahun (53,3%) dengan distribusi jenis kelamin seimbang, adenokarsinoma paling banyak ditemukan (86,7%), dan stage IV paling sering saat diagnosis (78,3%). Riwayat keluarga kanker paru relatif rendah, yakni 8,3% pada orang tua, 5% pada anak, dan 3,3% pada saudara kandung, dan analisis Mann–Whitney menunjukkan tidak terdapat hubungan signifikan antara riwayat keluarga dengan stadium kanker paru (p > 0,05). Jenis kanker paru hanya menunjukkan satu hubungan signifikansi dan selebihnya tidak. Hasil ini menunjukkan bahwa riwayat keluarga tidak berhubungan dengan karakteristik klinis kanker paru pada pasien di RSUP Persahabatan, sehingga faktor lingkungan dan gaya hidup kemungkinan lebih berperan dibanding faktor genetik.
Kata kunci: kanker paru, riwayat keluarga, stadium, adenokarsinoma, RSUP Persahabatan


Lung cancer is the leading cause of cancer-related deaths in Indonesia, and family history is often considered a genetic risk factor, although scientific evidence remains varied. This cross-sectional analytical study aimed to analyze the association between family history and the clinical characteristics of lung cancer patients at RSUP Persahabatan. Data were collected from 60 patients between March and August 2025 using questionnaires and medical records, including family history of cancer, stage, and type of lung cancer. The majority of patients were aged 45–59 years (53.3%) with an equal gender distribution, adenocarcinoma was the most common type (86.7%), and stage IV was the most frequent at diagnosis (78.3%). The prevalence of family history of lung cancer was relatively low: 8.3% in parents, 5% in children, and 3.3% in siblings, and Mann–Whitney analysis showed no significant association between family history and stage of lung cancer (p > 0.05). Type of cancer only showed one significant association, while the others were not significant. These findings indicate that family history is not associated with the clinical characteristics of lung cancer in patients at RSUP Persahabatan, suggesting that environmental and lifestyle factors may play a greater role than genetic factors.
Key words: lung cancer, family history, stage, adenocarcinoma, Persahabatan Hospital