Tesis

Hubungan Potensi Inflamasi Diet dengan Aktivitas Penyakit dan Kelelahan pada Lupus Eritematosus Sistemik = Dietary Inflammatory Index and its Association with Disease Activity and Fatigue in Systemic Lupus Erythematosus.

Background: Dietary inflammatory Potential has a substantial role on systemic inflammation in Systemic Lupus Erythematosus (SLE). Main outcomes for SLE are low disease activity until remission. Fatigue remains important clinical entity impacting SLE patient quality life and outcomes. Evidence regarding Dietary Inflammatory Index (DII) in Indonesian SLE populations is limited. Studies from diverse population and countries are inconsistent. Objective: The objectives were to determine the association between DII scores with disease activity (MEX-SLEDAI score), and fatigue levels (Fatigue Severity Scale,FSS score) in SLE. Mean DII scores was assessed for differences between remission and active disease. Additionally, DII scores’mean differences were analyzed according to fatigue status. Methods: A cross-sectional study was conducted among 97 SLE patients in RSUPN Dr. Cipto Mangunkusumo from October-November 2025. Dietary intake was converted into DII scores based on Shivappa et al algorithm. Multivariable logistic regression analysis performed to determine the association, adjusted for Age, BMI, Physical Activity, Sleep quality, Anxiety, Depression and Vitamin D level. Results: DII scores was not different in remission group compared to active SLE group (p=0,813). Nevertheless, DII Score was significantly different in fatigue group compared to non fatigue (p=0,013). Depression was a confounding factor for disease activity (p=0,013). Moreover, Vitamin D was a confounder in association between DII and MEX-SLEDAI (ΔPR 12,4). Fatigue was reported in 57,7% subject, although 80,4% ofthe population were in remission state. Decreased sleep quality and anxiety are covariates for fatigue ((p 0,016 and p