Skripsi

Analisis Hubungan Usia, Jenis Kelamin, dan Tingkat Keparahan Penyakit Terhadap Kualitas Hidup Pasien Miastenia Gravis di RSUPN Dr. Cipto Mangunkusumo = Analysis of the Relationship Between Age, Gender, and Disease Severity on the Quality of Life of Myasthenia Gravis Patients at RSUPN Dr. Cipto Mangunkusumo.

Latar Belakang Miastenia Gravis (MG) adalah gangguan neuromuskular yang menyebabkan kelemahan otot, yang memburuk saat aktivitas dan membaik setelah istirahat. Penelitian menunjukkan bahwa keparahan penyakit dan kecacatan berhubungan dengan penurunan kualitas hidup pasien, baik fisik maupun mental. Gangguan fisik akibat miastenia gravis memengaruhi aktivitas sehari-hari, termasuk pekerjaan. Kualitas hidup pasien dapat diukur menggunakan kuesioner MG-QoL-15, yang memberikan hasil yang reliabel. Meskipun faktor klinis berhubungan, data tentang hubungan faktor demografis di Indonesia masih terbatas. Penelitian ini bertujuan untuk mengeksplorasi hubungan antara karakteristik demografis, keparahan penyakit, dan riwayat pengobatan pada pasien miastenia gravis di RSCM. Metode Penelitian ini menggunakan desain studi analitik komparatif dengan metode crosssectional dan dilakukan di RSCM. Penelitian ini akan mengkaji hubungan karakteristik demografi dan karakteristik kualitas hidup pada pasien miastenia gravis yang datanya didapatkan dari wawancara pasien menggunakan kuesioner MG-QoL-15 setelah mendapat persetujuan pasien. Hasil Penelitian ini menganalisis 36 pasien miastenia gravis di RSCM dengan data yang diperoleh melalui wawancara dan rekam medis. Karakteristik demografis menunjukkan bahwa 55,6% subjek adalah perempuan dan 58,3% berusia 0,05). Kesimpulan Jenis kelamin, usia, dan derajat keparahan penyakit tidak berhubungan terhadap tingkat kualitas hidup pasien miastenia gravis.
Kata Kunci: Derajat keparahan penyakit, faktor demografis, kualitas hidup, miastenia gravis, MG-QoL-15


Introduction Myasthenia Gravis (MG) is a neuromuscular disorder that causes muscle weakness, which worsens during activity and improves with rest. Research has shown that the severity of the disease and disability are associated with a decline in the patient's quality of life, both physically and mentally. The physical impairments caused by Myasthenia Gravis affect daily activities, including work. The quality of life of patients can be measured using the MG-QoL-15 questionnaire, which provides reliable results. Although clinical factors have a significant impact, data on the influence of demographic factors in Indonesia is still limited. This study aims to explore the relationship between demographic characteristics, disease severity, and treatment history in Myasthenia Gravis patients at RSCM. Method This study uses a comparative analytical study design with a cross-sectional method and was conducted at RSCM. The study will examine the relationship between demographic characteristics and quality of life characteristics in Myasthenia Gravis patients, with data obtained from patient interviews using the MG-QoL-15 questionnaire, after receiving patient consent. Results This study analyzes 36 Myasthenia Gravis patients at RSCM with data obtained through interviews and medical records. The demographic characteristics show that 55.6% of the subjects are female and 58.3% are under 50 years old. The most common disease severity is Class I (38.9%). Quality of life was measured using the MG-QoL-15 questionnaire, which showed that 47.2% of the subjects had good quality of life, while 52.8% had poor quality of life. The results of the Fisher’s exact test indicated no significant relationship between demographic characteristics and disease severity with quality of life (p-value > 0.05). Conclusion Gender, age, and disease severity do not affect the quality of life of Myasthenia Gravis patients.
Keywords: Demographic factors, disease severity, myasthenia gravis, MG-QoL-15, quality of life