Tesis

Nilai viskositas darah untuk prediksi jenis patologis stroke (stroke iskemik, stroke hemoragik, dan stroke mimic) di RSUPN Dr. Cipto Mangunkusumo = Blood Viscosity Values for Predicting Pathological Types of Stroke (Ischemic Stroke, Hemorrhagic Stroke, and Stroke Mimic) at Dr. Cipto Mangunkusumo National General Hospital.

Stroke merupakan penyebab utama morbiditas dan mortalitas dengan perbedaan tatalaksana yang signifikan antara stroke iskemik, hemoragik, dan stroke mimic. CT scan non-kontras sebagai baku emas kurang optimal dalam mendeteksi lesi iskemik dini, sehingga dibutuhkan pemeriksaan tambahan. Viskositas darah dan plasma berpotensi memberikan nilai diagnostik tambahan pada stroke akut. Penelitian ini bertujuan menganalisis perbedaan rerata viskositas darah dan plasma pada pasien stroke iskemik, hemoragik, dan mimic, serta menentukan titik potong nilai viskositas yang dapat memprediksi jenis patologis stroke. Penelitian potong lintang ini dilakukan di IGD RSUPN Dr. Cipto Mangunkusumo. Dari 97 pasien suspek stroke, 70 pasien memenuhi kriteria penelitian dan diperiksa viskositas darah dan plasma menggunakan Neo Mikrokapiler Digital. Analisis perbedaan rerata viskositas darah dan plasma dilakukan pada ketiga kelompok, kemudian ditentukan titik potong, sensitivitas, spesifisitas, PPV, dan NPV. Analisis faktor perancu menggunakan regresi Poisson setelah uji bivariat. Viskositas darah berbeda signifikan antara kelompok stroke iskemik dan stroke hemoragik dibandingkan dengan stroke mimic, sedangkan viskositas plasma tidak berbeda bermakna. Titik potong viskositas darah diperoleh sebesar 5,17 cP dengan sensitivitas sebesar 71,2%, spesifisitas 94,4%, PPV 97,37%, dan NPV 53,13% untuk prediksi stroke. Viskositas darah dan plasma berpotensi menjadi pemeriksaan tambahan dalam membantu prediksi jenis patologis stroke.
Kata kunci: Stroke; viskositas darah; viskositas plasma


Stroke is a leading cause of morbidity and mortality, with distinct management approaches for ischemic stroke, hemorrhagic stroke, and stroke mimics. Non-contrast CT, the gold standard, is suboptimal for early ischemic lesion detection, highlighting the need for complementary diagnostics. Blood and plasma viscosity may add diagnostic value in acute stroke. This cross-sectional study aimed to compare mean blood and plasma viscosity among ischemic, hemorrhagic, and mimic stroke patients, and to determine cutoff values predictive of stroke type. Conducted at the Emergency Department of Dr. Cipto Mangunkusumo National General Hospital, the study included 70 of 97 patients suspected of having a stroke who met the inclusion criteria. Blood and plasma viscosity were measured using the Neo Digital Microcapillary device. Differences in mean viscosity were analyzed across groups, and cutoff values with sensitivity, specificity, PPV, and NPV were determined. Poisson regression was used to control confounders after bivariate analysis. Blood viscosity differed significantly between ischemic and hemorrhagic strokes compared to stroke mimics, while plasma viscosity showed no significant difference. The optimal blood viscosity cutoff was 5.17 cP (sensitivity 71.2%, specificity 94.4%, PPV 97.37%, NPV 53.13%). Blood viscosity shows potential as a complementary diagnostic marker for stroke classification.
Keywords: Stroke; blood viscosity; plasma viscosity