Tesis

Korelasi Aktivitas Fisik dengan Resistensi Insulin, Kadar Irisin dan Rasio Lemak Otot pada Dewasa Muda = Correlation of Physical Activity and Insulin Resistance, Irisin Levels, Fat to Muscle Ratio in Young Adults.

Resistensi insulin merupakan faktor utama terjadinya sindroma metabolik. Modifikasi gaya hidup dengan aktivitas fisik pun menjadi pilihan utama dalam pencegahan dan pengelolaan resistensi insulin, salah satunya melalui mekanisme perbaikan rasio lemak otot (RLO) dan kerja irisin. Penelitian ini bertujuan untuk mengetahui korelasi antara aktivitas fisik Global Physical Activity Questionnaire (GPAQ) dengan resistensi insulin (HOMA-IR), kadar irisin dan RLO, serta korelasi kadar irisin dan RLO dengan resistensi insulin. Penelitian ini merupakan bagian dari penelitian besar Profil Metabolik dan Ekosistem Saluran Cerna pada Populasi Dewasa Muda Agustus-November 2019 dan tambahan pemeriksaan irisin dengan desain potong lintang dengan total 241 subjek (104 laki-laki dan 137 perempuan), pada pemeriksaan irisin hanya terdapat 28 subjek (14 lakilaki dan 14 perempuan). Pada hasil tidak terdapat korelasi antara aktivitas fisik dengan resistensi insulin (p = 0,290), tidak terdapat korelasi antara aktivitas fisik dengan kadar irisin (p = 0,216), terdapat korelasi antara aktivitas fisik dengan RLO (p = 0,003), dengan koefisien korelasi negatif lemah (r = -0,194), tidak terdapat korelasi yang signifikan antara irisin dengan resistensi insulin (p = 0,369), terdapat korelasi yang signifikan antara RLO dengan resistensi insulin (p = < 0,001) dengan koefisien korelasi positif lemahsedang (r = 0,342).
Kata kunci: Aktivitas fisik, Irisin, Rasio lemak otot, Resistensi insulin


Insulin resistance is a major factor of metabolic syndrome. Lifestyle modification, like regular physical activity, is considered as primary prevention and management of insulin resistance. The proposed mechanisms are to improvements the fat-to-muscle ratio (FMR) and mechanism of irisin. The aims of this study are to assess the correlation of physical activity measured by Global Physical Activity Questionnaire, (GPAQ) and insulin resistance (measured by Homeostasis Model Assessment for Insulin Resistance/HOMAIR), irisin levels, and the fat to muscle ratio. In addition, the correlations of irisin levels and FMR with insulin resistance were also evaluated. This research was part of “Metabolic Profile and Gut Ecosystem in Young Adults” conducted from August to November 2019. A cross-sectional study with additional irisin measurement. Total of 241 subjects (104 males and 137 females) were included, with irisin levels measured in 28 subjects (14 males and 14 females). The findings revealed no significant correlation between physical activity and insulin resistance (p = 0.290). no significant correlation between physical activity and irisin levels (p = 0,216). A weak negative correlation was observed between physical activity and the fat-to-muscle ratio (p = 0.003; r = –0.194). No significant correlation was found between irisin levels and insulin resistance (p = 0.369). On the other hand, there was a significant positive correlation between the fat to muscle ratio and insulin resistance (p < 0.001), with a weak-to-moderate correlation coefficient (r = 0.342).
Key words: Fat to Muscle Ratio, Insulin Resistance, Irisin, Physical Activity