Tesis

Korelasi antara Asupan Folat dan Kekuatan Genggam Tangan pada Pasien Kanker Kepala Leher dengan Malnutrisi = Correlation between Folate Intake and Hand Grip Strength in Head and Neck Cancer Patients with Malnutrition.

Latar Belakang: Pasien kanker kepala-leher (KKL) berisiko mengalami malnutrisi dan penurunan massa otot dan kekuatan otot sehingga kapasitas fungsional dan kualitas hidup menurun. Folat berperan dalam sintesis, perbaikan, dan metilasi DNA, serta meregulasi kadar homosistein yang berperan juga dalam sintesis dan regenerasi sel otot. Namun, keterkaitan antara asupan folat dengan kapasitas fungsional pada populasi tersebut belum banyak diteliti. Metode: Penelitian ini menggunakan desain potong lintang terhadap 53 pasien KKL dewasa dengan malnutrisi yang belum menjalani radiasi di RSUPN Dr.Cipto Mangunkusumo. Data asupan folat diperoleh melalui SQ-FFQ, sedangkan kapasitas fungsional diukur menggunakan kekutan genggam tangan (KGT) dengan dinamometer Jamar. Analisis korelasi digunakan untuk mengevaluasi hubungan antar variabel. Hasil: Dari 53 subjek dengan rerata usia 43,3 ± 11,2 tahun, terdapat 62,3% subjek laki-laki dan 77,4% subjek mengalami malnutrisi sedang. Asupan folat subjek 190,2 (59,2-644,0) mcg/hari, 90,6% pasien memiliki asupan folat di bawah angka kecukupan gizi yang dianjurkan. Hasil KGT sebesar 28,0 (12,0-45,0) kg, 56,6% subjek menunjukkan hasil normal. Tidak ditemukan hubungan yang bermakna secara statistik antara asupan folat dengan KGT (r = 0,205, p > 0,05). Kesimpulan: Penelitian ini tidak menemukan hubungan yang bermakna antara asupan folat dengan kapasitas fungsional pada pasien KKL dengan malnutrisi.
Kata kunci: folat, kanker kepala leher, kekuatan genggam tangan, malnutrisi.


Background: Head and neck cancer (HNC) patients are at risk of malnutrition and decreased muscle mass and muscle strength, resulting in decreased functional capacity and quality of life. Folate is involved in DNA synthesis, repair, and methylation processes, and it helps regulate homocysteine levels, which are important for the formation and regeneration of muscle cells. However, the relationship between folate intake and functional capacity in this population has not been widely studied. Methods: This study used a cross-sectional design on 53 adult HNC patients with malnutrition who had not undergone radiation at Dr. Cipto Mangunkusumo National Hospital. Folate intake data were obtained through SQ-FFQ, while functional capacity was measured using handgrip strength (HGS) with a Jamar dynamometer. Correlation analysis was used to evaluate the relationship between variables. Results: This study included 53 participants with a mean age of 43.3 ± 11.2 years; 62.3% were male, and 77.4% were classified as having moderate malnutrition. Subjects had a folate intake of 190.2 (59.2–644.0) mcg/day, with 90.6% of them consuming less than the recommended dietary allowance. HGS results were 28.0 (12.0-45.0) kg, 56.6% of subjects showed normal results. No statistically significant correlation was found between folate intake and handgrip strength (r = 0.205, p > 0.05). Conclusion: This study found no significant correlation between folate intake and functional capacity in head and neck cancer patients with malnutrition.
Keywords: folate, hand grip strength, head and neck cancer, malnutrition.