Tesis

Korelasi Antara Asupan Vitamin D dan Massa Lemak Tubuh Pasien Kanker dengan Malnutrisi = Correlation between Vitamin D Intake and Body Fat Mass in Cancer Patients with Malnutrition.

Latar Belakang: Kejadian malnutrisi pada pasien kanker sebesar 70%. Vitamin D aktif (kalsitriol) dapat menghambat lipolisis basal adiposit pada kultur adiposit subkutan manusia. Namun, hubungan antara asupan vitamin D dengan massa lemak tubuh pada subjek malnutrisi masih belum diteliti. Metode: Penelitian ini menggunakan desain potong lintang terhadap pasien kanker dengan malnutrisi di RSCM. Data asupan vitamin D diperoleh melalui wawancara, sedangkan massa lemak tubuh diperoleh dengan pengukuran komposisi tubuh dengan BIA (bioelectrical impedance analysis) Seca® mBCA 525. Uji korelasi digunakan untuk mengevaluasi hubungan antar variabel. Hasil: Penelitian ini melibatkan 52 subjek dengan median usia 46 (18-59) tahun dan derajat malnutrisi sedang secara klinis. Asupan vitamin D subjek rerata 12,2 (0,3-131,7) mcg/hari dan rerata massa lemak tubuh 20,8±11,7%. Tidak terdapat korelasi antara asupan vitamin D dan massa lemak tubuh (r =- 0,202, p = 0,152). Kesimpulan: Tidak terdapat korelasi antara asupan vitamin D dan massa lemak tubuh pasien kanker dengan malnutrisi.
Kata kunci: Kanker, malnutrisi, massa lemak


Background: The incidence of malnutrition in cancer patients is 70%. Active vitamin D (calcitriol) can inhibit basal adipocyte lipolysis in human subcutaneous adipocyte cultures. However, the relationship between vitamin D intake and body fat mass in malnourished subjects has not been studied. Methods: This study used a cross-sectional design on cancer patients with malnutrition at RSCM. Data on vitamin D intake were obtained through interviews, while body fat mass was obtained by measuring body composition with BIA (bioelectrical impedance analysis) Seca® mBCA 525. Correlation test was used to evaluate the relationship between variables. Results: This study involved 52 subjects with a median age of 46 (18-59) years and a clinically moderate degree of malnutrition. Vitamin D intake averaged 12.2 (0.3-131.7) mcg/day and the average body fat mass was 20.8±11.7%. There was no correlation between vitamin D intake and body fat mass (r = - 0.202, p = 0.152). Conclusion: There was no correlation between vitamin D intake and body fat mass in cancer patients with malnutrition.
Keywords: Cancer, malnutrition, fat mass