Tesis

Hubungan Antara Asupan Seng dengan Selera Makan Pada Pasien Kanker di RSUPN CiptoMangunkusumo = Association Between Dietary Zinc Intake and Appetite in Cancer Patients at Cipto Mangunkusumo National General Hospital.

Latar Belakang: Pasien kanker rentan mengalami malnutrisi karena adanya penurunan selera makan yang disebabkan oleh faktor tumor ataupun karena adanya inflamasi sistemik. Malnutrisi menyebabkan defisiensi mikronutrien, salah satunya seng. Seng berperan menurunkan faktor inflamasi dan progresifitas tumor sehingga dapat meningkatkan selera makan pada pasien kanker. Penelitian ini bertujuan untuk mengetahui hubungan antara selera makan dengan selera makan pada pasien kanker di RSUPN Cipto Mangunkusumo. Metode: Penelitian cross sectional dilakukan pada pasien kanker yang belum mendapatkan terapi di Rumah Sakit Cipto Mangunkusumo. Asupan seng dinilai dengan cara wawancara menggunakan SQ-FFQ dan selera makan dinilai dengan menggunakan kuesioner SNAQ Skor yang telah dimodifikasi dalam Bahasa Indonesia. Analisis data dilakukan menggunakan uji Spearman dan Mann-Whitney. Hasil: Penelitian ini melibatkan 66 subjek dengan median usia 47 (22-59) tahun, sebagian besar berjenis kelamin perempuan, dan lebih dari 50% dengan status gizi malnutrisi berdasarkan ASPEN. Indeks massa tubuh (IMT) didapatkan sebagian besar dengan berat badan normal. Asupan seng pada penelitian ini didapatkan median 5 mg/hari (1,6-30,8) mg/hari. Skor selera makan dengan menggunakan SNAQ score dalah 13 (8-19). Terdapat hubungan yang signifikan antara asupan seng dengan selera makan (r = 0,566, p= < 0,001). Terdapat perbedaan skor selera makan berdasarkan asupan seng (p= < 0,001). Kesimpulan: Terdapat hubungan yang signifikan antara asupan seng dengan selera makan dan perbedaan skor selera makan berdasarkan asupan seng pada pasien kanker yang belum mendapatkan terapi di RSUPN Cipto Mangunkusumo.
Kata kunci: Asupan Seng, Kanker, Status gizi, Malnutrisi, Selera Makan


Background: Patients with cancer are vulnerable to malnutrition due to decreased appetite, which may be caused by tumor-related factors or systemic inflammation. Malnutrition causes micronutrient deficiencies, one of which is zinc. Zinc plays a role in reducing inflammatory factors and tumor progression, which may help improve appetite in cancer patients. This study aims to examine the relationship between zinc intake and appetite in cancer patients at Cipto Mangunkusumo National General Hospital. Methods: A cross-sectional study was conducted on cancer patients who had not yet received therapy at Cipto Mangunkusumo Hospital. Zinc intake was assessed through interviews using a semi-quantitative food frequency questionnaire (SQFFQ), and appetite was measured using a modified Indonesian version of the Simplified Nutritional Appetite Questionnaire (SNAQ). Data were analyzed using the Spearman correlation test and Mann-Whitney. Results: 66 subjects with a median age of 47 years (range: 22–59), the majority of whom were female, with over 50% classified as malnourished with ASPEN criteria. The Body Mass Index (BMI) was found to be within the normal weight range for the majority of subjects. The median zinc intake was 5 mg/day (range: 1.6–30.8 mg/day). The median SNAQ score was 13 (range: 8–19). There was a significant relationship between zinc intake and appetite (r = 0.566, p < 0.001). There was a significant difference in appetite scores based on zinc intake (p < 0.001). Conclusion: There was a significant association between dietary zinc intake and appetite and there was the difference in appetite scores based on zinc intake among cancer patients who have not yet undergone therapy at Cipto Mangunkusumo National General Hospital.
Keywords: Zinc Intake, Cancer, Nutritional Status, Malnutrition, Appetite