Tesis

Hubungan antara Kadar Seng Rambut Terhadap Indeks Massa Otot Pada Pasien Kanker Kepala Leher dengan Malnutrisi di RSUPN Cipto Mangunkusumo = Correlation between Hair Zinc Levels and Muscle Mass Index in Head and Neck Cancer Patients with Malnutrition at Dr. Cipto Mangunkusumo National Hospital.

Latar Belakang: Pasien kanker kepala leher berisiko mengalami gangguan fungsional dan malnutrisi yang dapat menyebabkan penurunan massa otot rangka. Seng merupakan mikronutrien esensial yang diperlukan untuk metabolisme protein dan berkontribusi terhadap sintesis protein. Kadar seng dapat memengaruhi sintesis protein sehingga meningkatkan risiko penurunan massa otot pada pasien kanker. Hingga saat ini belum banyak penelitian yang mengevaluasi hubungan antara kadar seng rambut dengan indeks massa otot pada kanker kepala leher. Metode: Penelitian ini merupakan studi potong lintang pada 57 pasien dewasa (18 tahun atau lebih) dengan kanker kepala leher yang belum menjalani radiasi di RSUPN Dr. Cipto Mangunkusumo. Dilakukan pemeriksaan kadar seng rambut dan indeks massa otot menggunakan alat BIA Seca bedridden. Analisis korelasi Spearman digunakan untuk menilai hubungan antara kadar seng rambut dan indeks massa otot. Hasil: Dari total 57 subjek, didapatkan nilai tengah dari kadar seng rambut adalah 130,1(22,35-1135,76) Sebanyak 37,1% subjek laki-laki dan 40,9% subjek perempuan memiliki nilai indeks massa otot yang rendah. Analisis bivariat menunjukkan adanya hubungan antara kadar seng rambut dengan indeks massa otot pada pasien kanker kepala leher yang belum menjalani radiasi (r=0,289; p= 0,029). Analisis berdasarkan jenis kelamin juga menunjukkan adanya hubungan sedang yang signifikan yaitu lakilaki (r=0,416; p=0,013) dan perempuan (r=0,444; p=0,038) Kesimpulan: Terdapat korelasi rendah yang signifikan antara kadar seng rambut dan indeks massa otot pada pasien kanker kepala leher yang belum menjalani radiasi.
Kata Kunci: seng, kadar seng rambut, indeks massa otot, kanker kepala leher


Background: Head and neck cancer patients are at risk of functional impairment and malnutrition, which can lead to a loss of skeletal muscle mass. Zinc is an essential micronutrient required for protein metabolism and contributes to protein synthesis. Zinc levels can influence protein synthesis, thereby increasing the risk of muscle mass loss in cancer patients. To date, few studies have evaluated the relationship between hair zinc levels and muscle mass index in head and neck cancer. Methods: This study was a cross-sectional study involving 57 adult patients (aged 18 years or older) with head and neck cancer who had not yet undergone radiation therapy at Dr. Cipto Mangunkusumo National General Hospital. Zinc levels were measured using hair samples, and muscle mass index was assessed using the Seca Bedridden BIA device. Spearman correlation analysis was used to evaluate the relationship between hair zinc levels and muscle mass index. Results: The median hair zinc level was found to be 1 30,1(22,35-1135,76). A total of 37,1% of male subjects and 40,9% of female subjects had a low muscle mass index. Bivariate analysis showed a significant correlation between hair zinc levels and muscle mass index in head and neck cancer patients who had not yet undergone radiotherapy (r = 0,289; p = 0,029). Gender-based analysis also demonstrated moderate significant correlations in males (r = 0,416; p = 0,013) and in females (r = 0,444; p = 0,038). Conclusion: A significant low relationship was found between hair zinc levels and muscle mass index in head and neck cancer patients who had not yet undergone radiation therapy.
Keywords: zinc, hair zinc levels, muscle mass index, head and neck cancer