Tesis

Volume Bulbus dan Kedalaman Sulkus Olfaktorius Normal berdasarkan Magnetic Resonance Imaging Populasi Dewasa Indonesia dan Hubungannya dengan Jenis Kelamin = Normal Olfactory Bulb Volume and Sulcus Depth Based on Magnetic Resonance Imaging in the Adult Indonesian Population and Their Relationship with Sex.

Latar belakang: Volume bulbus olfaktorius (BO) dan kedalaman sulkus olfaktorius (SO) merupakan parameter yang dapat digunakan untuk menilai fungsi penghidu. Berbagai penelitian mengukur nilai kedua parameter ini menggunakan pemeriksaan Magnetic Resonance Imaging (MRI), dan menemukan hubungan dengan berbagai kondisi patologis baik kongenital maupun didapat.. Saat ini belum ada data nilai normal volume BO dan kedalaman SO pada populasi dewasa di Indonesia. Metode: Pengukuran volume BO dan kedalaman SO dilakukan pada 178 pasien yang memenuhi kriteria penelitian. Analisis deskriptif dilakukan pada volume BO dan kedalaman SO dengan data dalam bentuk rerata dan standar deviasi. Pengukuran dilakukan menggunakan data sekunder yang diambil secara retrospektif. melalui sistem Picture Archiving Communication System (PACS) Departemen Radiologi RSUPN dr. Cipto Mangunkusumo. Analisis perbedaan rerata volume BO dan SO berdasarkan jenis kelamin dan sisi tubuh dilakukan menggunakan uji student-T tidak berpasangan. Hasil: Rerata usia subjek penelitian ialah 34,9±9,4 tahun. Didapatkan rerata volume BO laki-laki 71,9±22,1 mm3 (kanan: 75,2±25,1 mm3; kiri: 68,6±23,6 mm3) dan perempuan 63,4±18,1 mm3 (kanan: 65,0±21,2 mm3; kiri: 61,8±19,6 mm3). Rerata kedalaman SO laki-laki 7,5±1,3 mm (kanan: 7,8±1,5 mm; kiri: 7,1±1,4 mm) dan perempuan 7,3±1,2 mm (kanan: 7,6±1,3 mm; kiri 6,9±1,5 mm). Kesimpulan: Terdapat hubungan antara volume BO dengan jenis kelamin, dimana laki-laki memiliki volume BO yang lebih besar dibandingkan perempuan. Sementara itu tidak terdapat perbedaan signifikan kedalaman SO di antara jenis kelamin. Kedalaman SO kanan lebih besar signifikan dibandingkan kiri, meskipun perbedaan sisi tubuh tidak berpengaruh terhadap volume BO.
Kata kunci: Bulbus olfaktorius, sulkus olfaktorius, Magnetic Resonance Imaging


Background: The volume of the olfactory bulb (OB) and the depth of the olfactory sulcus (OS) are parameters that can be used to assess olfactory function. Various studies have measured the values of these two parameters using Magnetic Resonance Imaging (MRI) and have found associations with various pathological conditions, both congenital and acquired. Currently, there are no available data on the normal values of OB volume and OS depth in the adult population in Indonesia. Methods: Measurements of OB volume and OS depth were conducted on 178 patients who met the study criteria. Descriptive analysis was performed on OB volume and OS depth, with the data presented as mean and standard deviation. Measurements were obtained using secondary data collected retrospectively from the Picture Archiving and Communication System (PACS) of the Radiology Department, Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo). Differences in the mean OB volume and OS depth based on sex and body side were analyzed using an independent Student’s t-test. Results: The mean age of the study subjects was 34.9 ± 9.4 years. The mean OB volume for male was 71.9 ± 22.1 mm³ (right: 75.2 ± 25.1 mm³; left: 68.6 ± 23.6 mm³), and for female was 63.4 ± 18.1 mm³ (right: 65.0 ± 21.2 mm³; left: 61.8 ± 19.6 mm³). The mean OS depth for male was 7.5 ± 1.3 mm (right: 7.8 ± 1.5 mm; left: 7.1 ± 1.4 mm), and for female was 7.3 ± 1.2 mm (right: 7.6 ± 1.3 mm; left: 6.9 ± 1.5 mm). Conclusion: There is a significant relationship between OB volume and sex, with males having a larger OB volume than females. Meanwhile, there was no significant difference in OS depth between sexes. However, the right OS depth was significantly greater than the left, even though body side differences did not affect OB volume.
Keywords: Olfactory bulb, olfactory sulcus, Magnetic Resonance Imaging