Tesis

Korelasi Nilai Fibrosis-4, Nilai Albumin-Bilirubin, Kadar Asam urat Serum Terhadap Tingkat Keparahan Steatosis dan Fibrosis pada Metabolic dysfunction Associated Fatty Liver Disease (MAFLD) = The Correlation of Fibrosis-4 Score, Albumin-Bilirubin Score, and Serum Uric Acid Levels with the Severity of Steatosis and Fibrosis in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).

Latar Belakang: Penilaian derajat keparahan Metabolic dysfunction Associated Fatty Liver Disease (MAFLD) secara non-invasif menjadi penting mengingat keterbatasan akses terhadap pemeriksaan pencitraan atau biopsi hati. Parameter yang diukur dengan hasil laboratorium seperti FIB-4, ALBI, dan kadar asam urat serum telah banyak digunakan dalam berbagai kondisi hepatik, namun belum diketahui secara pasti apakah terdapat korelasi antara ketiganya dengan tingkat keparahan steatosis dan fibrosi pada MAFLD. Oleh karena itu, penelitian ini bertujuan untuk mengevaluasi korelasi ketiga parameter tersebut terhadap tingkat keparahan steatosis dan fibrosis pada MAFLD yang diukur menggunakan Controlled Attenuation Parameter Transient Elastography (CAP-TE) Tujuan: Mengetahui korelasi antara nilai FIB-4, nilai ALBI, dan kadar asam urat serum dengan derajat keparahan MAFLD. Metode: Penelitian ini merupakan studi observasional analitik dengan pendekatan potong lintang. Sebanyak 116 pasien MAFLD yang menjalani pemeriksaan CAPTE di RSUPN Cipto Mangunkusumo dianalisis. Korelasi antara parameter FIB-4, ALBI, dan kadar asam urat terhadap nilai CAP dan elastisitas hati dianalisis menggunakan uji statistik sesuai distribusi data. Hasil: Ditemukan korelasi positif yang signifikan antara kadar asam urat serum dengan tingkat fibrosis (r = 0,309; p = < 0,001). Kadar asam urat tidak menunjukkan korelasi signifikan terhadap nilai CAP, dan parameter FIB-4 serta ALBI tidak menunjukkan korelasi yang bermakna terhadap keparahan MAFLD. Kesimpulan: Kadar asam urat serum menunjukkan korelasi yang bermakna dengan tingkat fibrosis hati pada pasien MAFLD, khususnya terhadap nilai liver stiffness. Hasil ini menunjukkan bahwa asam urat berpotensi sebagai salah satu parameter awal dalam menilai fibrosis hati secara non-invasif.
Kata Kunci: MAFLD, korelasi, FIB-4, ALBI, asam urat, CAP, elastisitas hati


Background : Non-invasive assessment of the severity of Metabolic dysfunction-Associated Fatty Liver Disease (MAFLD) is crucial due to limited access to imaging modalities or liver biopsy. Laboratory-based parameters such as FIB-4, ALBI, and serum uric acid levels have been widely used in various hepatic conditions; however, it remains unclear whether these parameters correlate with the severity ofsteatosis and fibrosis in MAFLD. Therefore, this study aims to evaluate the correlation of these three parameters with MAFLD severity, as measured by Controlled Attenuation Parameter-Transient Elastography (CAP-TE). Objective : This study aims to determine the correlation between FIB-4, ALBI scores, and serum uric acid levels with the severity of MAFLD.. Methods: This was an analytical observational study with a cross-sectional design. A total of 116 patients with MAFLD who underwent CAP-TE examination at RSUPN Cipto Mangunkusumo were analysed. Correlations between FIB-4, ALBI, and serum uric acid levels with CAP values and liver stiffness were assessed using statistical tests based on data distribution. Results: A significant positive correlation was found between serum uric acid levels and liver stiffness measurement (r = 0.309; p < 0.001). No significant correlation was observed between serum uric acid and CAP values. Additionally, FIB-4 and ALBI did not show meaningful correlations with MAFLD severity. Conclusion: Serum uric acid levels showed a significant correlation with the degree of liver fibrosis in MAFLD patients, particularly with liver stiffness values. These findings suggest that uric acid has potential as an early non-invasive parameter for assessing liver fibrosis.
Keywords: MAFLD, correlation, FIB-4, ALBI, uric acid, CAP, liver stiffness