Tesis

Peran Probiotik terhadap Depresi dan Kualitas Hidup pada pasien Irritable Bowel Syndrome = The Role of Probiotics in Depression and Quality of Life among Patients with Irritable Bowel Syndrome.

Latar Belakang: Irritable Bowel Syndrome (IBS) merupakan gangguan gastrointestinal fungsional yang sering disertai dengan gangguan psikologis seperti depresi dan penurunan kualitas hidup. Intervensi probiotik telah dikaji sebagai terapi tambahan yang potensial untuk mengatasi gangguan psikologis dan meningkatkan kualitas hidup pasien IBS. Tujuan: Menilai efek pemberian probiotik terhadap gejala depresi dan kualitas hidup pasien IBS di RSUPN dr. Cipto Mangunkusumo menggunakan instrumen Beck Depression Inventory-II (BDI-II) dan SF-36. Metode: Penelitian ini merupakan uji klinis acak tersamar ganda dengan desain kontrol sebelum-setelah intervensi. Sebanyak 70 peserta secara acak menjadi dua kelompok, yaitu kelompok intervensi (n=35) yang mendapatkan probiotik dan kelompok kontrol yang mendapatkan plasebo (n=35). Gejala depresi dinilai menggunakan BDI, sedangkan kualitas hidup diukur dengan SF-36 sebelum dan setelah intervensi. Analisis statistik menggunakan uji Mann-Whitney dan uji t independen, dengan signifikansi p < 0,05. Hasil: Setelah intervensi, kelompok probiotik menunjukkan penurunan bermakna skor BDI dibandingkan plasebo (p < 0,0001). Selain itu, terdapat peningkatan bermakna pada hampir seluruh domain SF-36 pada kelompok probiotik dibandingkan plasebo, termasuk fungsi fisik, keterbatasan fisik, nyeri tubuh, kesehatan umum, vitalitas, fungsi sosial, kesehatan emosional, dan kesehatan mental (p < 0,0001). Simpulan: Pemberian probiotik secara signifikan menurunkan gejala depresi dan meningkatkan kualitas hidup pada pasien IBS. Hasil ini mendukung potensi probiotik sebagai terapi tambahan dalam manajemen IBS yang komprehensif.
Kata kunci: Probiotik, Irritable Bowel Syndrome, Depresi, Kualitas Hidup, BDIII, SF-36


Background: Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder frequently accompanied by psychological disturbances such as depression and reduced quality of life. Probiotic intervention has been studied as a potential adjunct therapy to address psychological symptoms and improve the quality of life in IBS patients. Objective: To evaluate the effect of probiotic supplementation on depressive symptoms and quality of life in IBS patients at Dr. Cipto Mangunkusumo National General Hospital using the Beck Depression Inventory-II (BDI-II) and SF-36 instruments. Methods: This study was a double-blind randomized controlled trial with a prepost intervention design. A total of 70 participants were randomly assigned into two groups: the intervention group (n=35), which received probiotics, and the control group (n=35), which received a placebo. Depressive symptoms were assessed using the BDI-II, while quality of life was measured using the SF-36 questionnaire, both before and after the intervention. Statistical analysis was performed using the Mann-Whitney test and independent t-test, with a significance level of p < 0.05. Results: After the intervention, the probiotic group showed a significant reduction in BDI-II scores compared to the placebo group (p < 0.0001). In addition, the probiotic group demonstrated significant improvements in almost all domains of the SF-36 compared to the placebo group, including physical functioning, role physical, bodily pain, general health, vitality, social functioning, emotional wellbeing, and mental health (p < 0.0001). Conclusion: Probiotic supplementation significantly reduces depressive symptoms and improves quality of life in IBS patients. These findings support the potential of probiotics as an adjunct therapy in the comprehensive management of IBS.
Keywords: Probiotics, Irritable Bowel Syndrome, Depression, Quality of Life, BDI-II, SF-36