Tesis

Gambaran Kadar Vitamin 25(OH)D Serum pada Pasien Tuberkulosis Intestinal di RSUPN dr. Cipto Mangunkusumo = 25(OH) Vitamin D Serum Level Profile of Intestinal Tuberculosis Patients at RSUPN dr. Cipto Mangunkusumo.

Tuberkulosis (TB) disebabkan oleh Mycobacterium tuberculosis (MTB). Organ utama infeksi MTB adalah paru, namun dapat terjadi infeksi ekstrapulmonal ke organ lain seperti pleura, tulang, kulit, meningeal, saluran genitourinaria, organ rongga abdomen, dan lainnya. Salah satu bentuk TB di rongga abdomen adalah TB intestinal (TBI). Vitamin D berperan dalam respon imun terhadap infeksi termasuk yang disebabkan oleh MTB. Bentuk aktif vitamin D, calcitriol (1,25(OH)D), digunakan untuk proses autofagi, fagolisosom, pembentukan katelisidin, dan efek killing MTB, namun status vitamin D seseorang dinilai dengan mengukur kadar vitamin 25(OH)D di dalam darah. Penelitian ini bertujuan mengetahui kadar vitamin 25(OH)D pada penderita TBI di Indonesia. Penelitian ini melibatkan 40 subjek terdiri dari masing-masing 20 subjek kelompok TBI dan non-TBI. Didapatkan median kadar vitamin 25(OH)D kelompok TBI 9,8 ng/mL (4,5 – 32,6 ng/mL) dan median kelompok non-TBI 18,4 ng/mL (6,5 – 29,9 ng/mL). Uji statistik menunjukkan perbedaan bermakna median kedua kelompok dengan p value = 0,025.
Kata kunci: Kadar vitamin 25(OH)D, TB intestinal, TBI, calcidiol


Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB). The main organ of MTB infection is the lungs, but extrapulmonary infection can occur in other organs such as the pleura, bones, skin, meninges, genitourinary tract, abdominal cavity organs, and others. One form of TB in the abdominal cavity is intestinal TB (TBI). Vitamin D plays a role in the immune response to infections, including those caused by MTB. The active form of vitamin D, calcitriol (1 .25(OH)D), is used for autophagy, phagolysosome processes, cathelicidin formation, and MTB killing effects, but a person's vitamin D status is assessed by measuring 25(OH) vitamin D levels in the blood. This study aimed to determine 25(OH) vitamin D levels in TBI patients in Indonesia. This study involved 40 subjects consisting of 20 subjects each in the TBI and non-TBI groups. The 25(OH) vitamin D level in TBI group were 9,8 ng/mL (4,5 – 32,6 ng/mL), and 18,4 ng/mL (6,5 – 29,9 ng/mL) in non-TBI group. Statistical test showed a significant difference in median between the two groups with p-value = 0,025.
Keywords: 25(OH) vitamin D level, intestinal TB, tuberculosis, calcidiol