Tesis

Korelasi Kadar Vitamin D Serum terhadap Aterosklerosis Subklinis pada Pasien dengan HIV Tersupresi Virologis dengan Seropositif Sitomegalovirus (CMV) = Correlation of Serum Vitamin D Levels Towards Subclinical Atherosclerosis in Patients with Virologically Suppressed HIV and Cytomegalovirus (CMV) Seropositive.

Latar belakang: Kondisi HIV tersupresi virologis dan seropositif sitomegalovirus (CMV) beresiko menyebabkan aterosklerosis subklinis. Vitamin D diketahui memiliki peran faktor protektif. Petanda yang dapat digunakan terhadap aterosklerosis subklinis adalah flow mediated dilation (FMD). Belum terdapat penelitian terkait FMD dengan kadar vitamin D serum di Indonesia pada kelompok populasi tersebut. Tujuan: Mengetahui korelasi antara kadar vitamin D dengan FMD pada pasien HIV tersupresi virologis dengan seropositif CMV. Metode: Desain penelitian adalah potong lintang, data penelitian terdiri dari data primer yaitu kadar vitamin D dan data sekunder yaitu FMD. Populasi target adalah pasien dengan HIV tersupresi virologis dengan seropositif CMV. Pengukuran kadar vitamin D menggunakan metode ELISA dan FMD menggunakan ultrasound. Analisa statistika menggunakan uji korelasi Spearman. Hasil: Empat puluh enam subjek penelitian memiliki rerata kadar vitamin D serum 19.76 ng/mL dan hanya sebanyak 6 subjek (13%) memiliki kadar vitamin D normal. Rerata FMD adalah 7.52% dengan proporsi arterosklerosis subklinis sebanyak 54,3%. Terdapat korelasi kuat antara kadar vitamin D dengan nilai FMD (r=0.73). Kesimpulan: Korelasi kuat antara kadar vitamin D serum dan FMD pada pasien dengan HIV tersupresi virologis dan seropositif citomegalovirus (CMV).
Kata kunci: HIV tersupresi virologis, seropositif CMV, kadar vitamin D serum, flow mediated dilation (FMD).


Background: Virologically suppressed HIV and cytomegalovirus (CMV) seropositivity cause chronic inflammation and subclinical atherosclerosis. Vitamin D is known to have an anti-inflammatory role and a protective factor against it. A marker that can be used for subclinical atherosclerosis is flow mediated dilation (FMD), while there has been no research related to FMD in this population group and its relationship to serum vitamin D levels in Indonesia. Objective: To determine the correlation between vitamin D levels and FMD in patients with virologically suppressed HIV with CMV seropositivity. Method: The study design was cross-sectional, the research data consisted of primary data, namely vitamin D levels and secondary data, namely FMD. The target population was patients with HIV with CMV seropositivity. Measurement of vitamin D levels using the ELISA method and FMD using ultrasound. Statistical analysis using the Spearman correlation test. Results: Forty-six study subjects had an average serum vitamin D level of 19.76 ng/mL and only 6 subjects (13%) had normal vitamin D levels. Meanwhile, the average FMD was 7.52%. There was a strong correlation between vitamin D levels and FMD values (r=0.73). Conclusion: There was a strong correlation between serum vitamin D levels and FMD in patients with virologically suppressed HIV and cytomegalovirus (CMV) seropositivity.
Keywords: virologically suppressed HIV, CMV seropositivity, serum vitamin D levels, flow mediated dilation (FMD).