Skripsi

The Association Between Blood Glucose Levels and Severity of Covid-19 in Four Depok Referral Hospitals in 2020.

Latar belakang: Kadar glukosa darah diduga mempengaruhi tingkat keparahan COVID-19. Penelitian ini bertujuan untuk menyelidiki hubungan antara kadar glukosa darah saat masuk rumah sakit dengan tingkat keparahan COVID-19 pada pasien yang dirawat di empat rumah sakit rujukan di Depok, Indonesia.
Metode: Studi potong lintang ini melibatkan 254 pasien dewasa COVID-19 yang dirawat di empat rumah sakit rujukan di Depok dari bulan Juni hingga September 2020. Pasien dikategorikan menjadi dua kelompok berdasarkan tingkat keparahan COVID-19: ringan dan sedang/berat. Kadar glukosa darah saat masuk rumah sakit diklasifikasikan sebagai normal ( < 180 mg/dL) atau tinggi ( ≥ 180 mg/dL). Uji Pearson Chi-square digunakan untuk menilai hubungan antara kadar glukosa darah dan tingkat keparahan COVID-19. Analisis regresi linear dilakukan untuk menguji faktor perancu.
Hasil: Populasi penelitian terdiri dari 254 pasien, dengan 215 (84,6%) mengalami COVID-19 ringan dan 39 (15,4%) mengalami COVID-19 sedang/berat. Analisis tidak menunjukkan hubungan yang signifikan secara statistik antara kadar glukosa darah dan tingkat keparahan COVID-19 (p = 0,424). Analisis lebih lanjut terhadap faktor perancu seperti usia, jenis kelamin, PPOK, diabetes mellitus, hipertensi, dan obesitas tidak menunjukkan interaksi atau efek perancu yang signifikan terhadap hubungan antara kadar glukosa darah dan tingkat keparahan COVID-19.
Kesimpulan: Temuan dari penelitian ini menunjukkan bahwa tidak ada hubungan yang signifikan antara kadar glukosa darah saat masuk rumah sakit dengan tingkat keparahan infeksi COVID-19. Faktor perancu potensial tidak secara signifikan mengubah hubungan ini. Penelitian di masa mendatang dengan ukuran sampel yang lebih besar dan mempertimbangkan faktor tambahan diperlukan untuk lebih memahami potensi hubungan antara kadar glukosa darah dan tingkat keparahan COVID-19.

Kata kunci: COVID-19, tingkat glukosa darah, keparahan penyakit, studi cross-sectional, gula darah sewaktu



Introduction: Blood glucose levels have been hypothesized to affect the severity of COVID-19. This study aims to investigate the association between blood glucose levels upon hospital admission and the severity of COVID-19 in patients treated in four referral hospitals in Depok, Indonesia.

Method: This cross-sectional study included 254 adult COVID-19 patients admitted to four referral hospitals in Depok from June to September 2020. Patients were categorized into two groups based on COVID-19 severity: mild and moderate/severe. Blood glucose levels upon admission were classified as normal ( < 180 mg/dL) or high ( ≥ 180 mg/dL). The Pearson Chi-square test was used to assess the association between blood glucose levels and COVID-19 severity. A linear regression analysis was performed to test for confounding factors.
Results: The study population consisted of 254 patients, with 215 (84.6%) experiencing mild COVID-19 and 39 (15.4%) experiencing moderate/severe COVID-19. The analysis did not show a statistically significant association between blood glucose levels and COVID-19 severity (p = 0.424). Further analysis of confounding factors such as age, sex, COPD, diabetes mellitus, hypertension, and obesity revealed no significant interactions or confounding effects on the relationship between blood glucose levels and COVID-19 severity.
Conclusion: The findings of this study indicate that there is no significant association between blood glucose levels at the time of hospital admission and the severity of COVID-19 infection. Potential confounding factors did not significantly alter this relationship. Future research with larger sample sizes and consideration of additional factors is needed to better understand the potential relationship between blood glucose levels and COVID-19 severity.

Keywords: COVID-19, blood glucose levels, disease severity, cross-sectional study, random blood glucose