Tesis

Hubungan Kadar Glukosa Darah terhadap Populasi Sel T Regulator (CD4+CD25+FOXP3 +) pada Subyek Preeklampsia = Association Between Blood Glucose Levels and Regulatory T Cell Population (CD4+CD25+FOXP3 +) in Preeclampsia Subjects.

Preeklamsia merupakan komplikasi kehamilan yang ditandai dengan hipertensi dan proteinuria, mempengaruhi hampir 2-8% kehamilan di seluruh dunia. Di Indonesia, kejadian preeklamsia cukup tinggi yaitu 24%. Penelitian menunjukkan bahwa kadar glukosa darah yang tinggi pada gestational diabetes melitus berisiko mengalami preeklampsia pada kehamilan. Pada preeklampsia ditemukan populasi sel Treg signifikan lebih rendah pada desidua uterus ibu hamil preeklampsia. Penelitian ini akan membuktikkan apakah terdapat hubungan kadar glukosa darah terhadap persentase populasi sel T regulator. Teknik pengambilan sampel pada penelitian obsevasional ini yaitu metode purposive sampling dengan jumlah 24 orang untuk setiap kelompok. Sampel penelitian diambil dari Rumah Sakit Cipto Mangunkusumo, Rumah Sakit Budi Kemuliaan, dan Puskesmas Senen. Data yang digunakan adalah data primer dan sekunder yaitu flow cytometry dengan marker CD4+CD25+FOXP3 + dan rekam medis. Hasil statistik menunjukkan bahwa hubungan yang rendah antara kadar glukosa darah dan populasi Treg baik pada kelompok kontrol maupun preeklampsia, namun tren keduanya berbeda. Disimpulkan bahwa pada preeklampsia menunjukkan bahwa kadar glukosa darah tinggi memiliki kecenderungan penurunan jumlah sel Treg.
Kata kunci : Preeklampsia, glukosa darah, sel T regulator


Preeclampsia is a pregnancy complication characterized by hypertension and proteinuria, affecting approximately 2-8% of pregnancies worldwide. In Indonesia, the incidence of preeclampsia is notably high, reaching 24%. Research indicates that elevated blood glucose levels in gestational diabetes mellitus increase the risk of developing preeclampsia during pregnancy. In cases of preeclampsia, a significantly lower population of T regulatory (Treg) cells is observed in the uterine decidua of pregnant women with preeclampsia. This study aims to determine whether there is an association between blood glucose levels and the percentage of Treg cell population. The sampling technique used in this observational study was purposive sampling, with 24 participants in each group. The study samples were obtained from Cipto Mangunkusumo Hospital, Budi Kemuliaan Hospital, and Senen Health Center. The data used includes primary and secondary data, such as flow cytometry with markers CD4+CD25+FOXP3+ and medical records. Statistical results indicate a weak correlation between blood glucose levels and Treg cell population in both the control and preeclampsia groups, although the trends in each group differ. It is concluded that in preeclampsia, elevated blood glucose levels tend to correlate with a reduction in the number of Treg cells.
Keywords: Preeclampsia, blood glucose, regulatory T cell