Tesis

Kualitas Hidup Pasien Diabetes Melitus Awitan Muda dan Faktor-faktor yang Berhubungan = Quality of Life in Young-onset Diabetes Patients and Its Associated Factors.

Latar belakang: Diabetes melitus (DM) merupakan penyakit kronik metabolik dengan prevalensi semakin meningkat dan awitan semakin muda. Perjalanan penyakit DM awitan muda bersifat lebih agresif sehingga menyebabkan lebih tingginya morbiditas serta mortalitas yang terjadi pada usia relatif muda. Hingga kini, belum ada penelitian yang menilai kualitas hidup pasien DM awitan muda di Indonesia. Tujuan: Studi ini bertujuan untuk melihat kualitas hidup pasien DM awitan muda dan faktor yang berhubungan. Metode: Studi ini merupakan studi potong-lintang dengan mengambil data dasar dari registry genomic pasien DM usia ≥ 18 tahun dan terdiagnosis DM pada usia ≤ 40 tahun di RSCM pada periode September 2022 hingga April 2024. Peneliti mengambil data kualitas hidup secara wawancara dengan menggunakan kuesioner EQ-5D-5L dimana akan menampilkan skor kualitas hidup dalam bentuk median. Peneliti akan meneliti dan menganalisis hubungan faktor determinan dan kualitas hidup. Hasil: Peneliti memasukkan 241 subjek dalam penelitian ini. Nilai median kualitas hidup pasien DM awitan muda adalah 0,92. Pada analisis bivariat tampak bahwa komorbiditas DM, depresi, aktivitas fisik, kompleksitas terapi, dan komplikasi DM berhubungan dengan kualitas hidup pasien DM awitan muda. Kesimpulan: Kualitas hidup pasien DM awitan muda di Indonesia baik. Komplikasi, komorbiditas, depresi, aktivitas fisik, dan kompleksitas terapi berperan dalam penentu kualitas hidup pasien DM awitan muda.
Kata kunci: DM, awitan muda, kemandirian, kualitas hidup


Background: Diabetes mellitus (DM) is a metabolic chronic disease with increasing prevalence. The disease course of young-age DM is more aggressive, leading to higher morbidity and mortality that occurs at a relatively young age. Until now, there has been no specific study that assesses the quality of life of youngonset DM patients. Objectives: This study aims to look at the quality of life of young-onset DM patients and its influencing factors. Methods: This study is a cross-sectional study with baseline data taken from the genomic registry of DM patients aged ≥ 18 years and diagnosed with DM at age ≤ 40 years at RSCM from September 2022 to April 2024. Quality of life data were collected by interview using the EQ-5D-5L questionnaire where quality of life scores was displayed as medians. The relationship of determinant factors with quality of life were investigated and analyzed by bivariate and multivariate analyses. Results: A total of 241 subjects were included in this study. The median quality of life score of young DM patients was 0.92. Bivariate analysis showed that DM comorbidity, depression, physical activity, treatment complexity, and DM complications were associated with the quality of life of young DM patients. Multivariate analysis showed that treatment complexity was an important determinant of the quality of life of young DM patients. Conclusion: The quality of life of young-onset DM patients in Indonesia is good. Complications, comorbidities, depression, physical activity, and complexity of therapy play a role in determining the quality of life of young DM patients.
Keywords: diabetes mellitus, young-onset, quality of life