Tesis

Korelasi Kadar FT4 dengan Kadar Asam Urat dan Beda Rerata Asam Urat Subjek dengan dan Tanpa Atrial Fibrilasi pada Penyakit Graves = Correlation between Serum FT4 with Uric Acid and Comparison of Uric Acid in Participants with and without Atrial Fibrillation in Graves’ Disease.

Latar belakang: Penyakit kardiovaskular meningkatkan risiko mortalitas pada penyakit Graves (PG). Penyakit kardiovaskular terbanyak pada PG adalah atrial fibrilasi (AF). Kondisi hipertiroid pada PG dapat menyebabkan peningkatan asam urat. Asam urat meningkatkan risiko terjadinya AF pada populasi umum. Tujuan: Mengetahui korelasi T4 bebas (free T4, FT4) dengan asam urat dan beda rerata asam urat subjek dengan dan tanpa AF pada PG. Metode: Studi potong lintang dilakukan terhadap pasien PG yang memenuhi kriteria penelitian di RSUPN dr. Cipto Mangunkusumo pada tahun 2024. Subjek penelitian menjalani wawancara, pemeriksaan fisik, pemeriksaan laboratorium, dan elektrokardiografi. Analisis statistik dilakukan dengan korelasi Pearson atau Spearman, serta analisis bivariat untuk mencari beda rerata asam urat pada subjek dengan dan tanpa AF. Hasil: Penelitian ini mengikutsertakan 74 subjek dengan rerata usia 41 tahun, sebagian besar perempuan (86,5%), dan sebagian besar memiliki kadar FT4 normal (62,2%). Prevalensi AF pada studi ini sebesar 4,1%. Tidak terdapat korelasi bermakna antara FT4 dengan asam urat (r = 0,076; p = 0,520), termasuk setelah analisis subgrup berdasarkan status tiroid, jenis kelamin, dan diabetes melitus. Tidak terdapat perbedaan rerata asam urat bermakna antara subjek dengan dan tanpa AF (4,9 ± 1,01 mg/dl vs 4,7 ± 1,2 mg/dl; p = 0,785). Kesimpulan: Tidak terdapat korelasi FT4 dan asam urat pada PG. Tidak terdapat beda rerata asam urat bermakna antara subjek dengan dan tanpa AF pada PG.
Kata kunci: asam urat, atrial fibrilasi, penyakit Graves, T4 bebas

Background: Cardiovascular diseases are associated with an increased mortality risk in Graves’ disease (GD) patients. Meanwhile, atrial fibrillation (AF) is one of the most prevalent cardiovascular diseases in GD. Hyperthyroidism in GD may increase uric acid levels, which may also elevate the risk of AF in the general population. Objective: To observe correlation between free T4 (FT4) and uric acid, as well as comparison of uric acid in participants with and without AF in GD. Method: A cross-sectional study was conducted on GD patients who met the inclusion criteria at Dr. Cipto Mangunkusumo Hospital in 2024. Data were collected through history taking, physical and laboratory examination, as well as electrocardiogram (ECG) for each participant. Subsequently, data were analyzed using Pearson or Spearman correlation, as well as bivariate analysis to evaluate comparison of uric acid in participants with and without AF. Results: The results showed that 74 participants were included with a mean age of 41 years, mostly female (86.5%) and 62.2% had normal FT4 levels. AF occurred only in 4.1% of participants and the mean of uric acid was 4.71 ± 1.2 mg/dl, falling within the normal range. There was no correlation between FT4 and uric acid (r = 0.076; p = 0.520), including after adjustment with subgroup analysis based on thyroid status, gender, and diabetes mellitus. The mean of uric acid was not statistically different between participants with and without AF (4.9 ± 1.01 mg/dl vs 4.7 ± 1.2 mg/dl; p = 0.785). Conclusion: Based on the results, no significant correlation was found between FT4 and uric acid. The mean of uric acid was not statistically different between participants with and without AF.
Keywords: Atrial fibrillation, FT4, Graves’ disease, Uric acid