Tesis

Hubungan antara Kolelitiasis dengan Kejadian Right-sided colon cancer di RSCM = Association between Cholelithiasis and the Incidence of Right-sided Colon Cancer in RSCM.

Latar belakang: Kanker kolorektal merupakan salah satu penyebab mortalitas tertinggi akibat kanker urutan ketiga di dunia. Terdapat perbedaan gejala hingga prognosa pada lokasi kanker kolon. Right-sided colon cancer bersifat asimtomatik, diferensiasi buruk, dan prognosa lebih buruk. Kolelitiasis dikatakan memiliki hubungan dengan Right-sided colon cancer akibat adanya disregulasi asam empedu yang menyebabkan stress oksidatif mukosa kolon. Tujuan: Mengetahui hubungan antara kolelitiasis dengan kejadian Right-sided colon cancer Metode: Penelitian ini menggunakan desain potong lintang untuk menilai kolelitiasis dengan kejadian Right-sided colon cancer. Penelitian dilakukan di RS Cipto Mangunkusumo pada bulan Juni 2024. Kriteria inklusi penelitian ini pasien dewasa di atas 18 tahun yang dilakukan kolonoskopi atau reseksi, pasien yang terdiagnosa kanker kolon berdasarkan hasil patologi anatomi, dan pasien yang sudah memiliki hasil CT scan abdomen. Kriteria eksklusi adalah pasien dengan data rekam medis yang tidak lengkap. Analisa data menggunakan chi-square dan analisis multivariat regresi logistik. Hasil: Dari total 164 pasien ditemukan bahwa adanya hubungan antara kolelitiasis dengan kejadian right-sided colon cancer (nilai p = 0,002). Kolelitiasis memiliki hubungan dengan kejadian right-sided colon cancer dengan PR 1,8 (IK 95% 1,257 – 2,849). Pada penelitian ini tidak ditemukan juga adanya faktor perancu antara kolelitiasis dengan right-sided colon cancer dengan fully adjusted PR (IK 95%) adalah 1,861 (IK 95% 1,207 – 2,871) dengan p 0,005. Kesimpulan: Adanya hubungan antara kolelitiasis dengan kejadian right-sided colon cancer. Kolelitiasis berisiko sebesar 1,8 kali terhadap kejadian right-sided colon cancer
Kata kunci: kanker kolon, kolelitiasis, right-sided colon cancer


Background: Colorectal cancer is one of the leading causes of cancer-related mortality worldwide. There are differences in symptoms and prognosis depending on the location of colon cancer. Right-sided colon cancer is typically asymptomatic, poorly differentiated, and has a worse prognosis. Cholelithiasis is suggested to be associated with right-sided colon cancer due to bile acid dysregulation leading to oxidative stress on the colonic mucosa. Aim: To determine the association between cholelithiasis and the incidence of right-sided colon cancer. Method: This study is a cross-sectional study to assess the association between cholelithiasis and the incidence of right-sided colon cancer. The research was conducted at RS Cipto Mangunkusumo in June 2024. Inclusion criteria were adult patients over 18 years old who underwent colonoscopy or resection, patients diagnosed with colon cancer based on anatomical pathology results, and patients who had undergone abdominal CT scan. Exclusion criteria included patients with incomplete medical records. Data analysis used chisquare and multivariate logistic regression analysis. Results: From 164 patients, it was found that there is an association between cholelithiasis and the incidence of right-sided colon cancer (p-value = 0.002). Cholelithiasis is associated with right-sided colon cancer with prevalence risk of 1.8 times (95% CI 1.257 – 2.849). No confounding factors were found between cholelithiasis and right-sided colon cancer in this study, with fully adjusted prevalence risk of 1.861 (95% CI 1.207 – 2.871) with p-value 0.005. Conclusion: There is association between cholelithiasis and the incidence of right-sided colon cancer. Cholelithiasis has 1.8 times increased risk for the occurrence of right-sided colon cancer.
Keywords: cholelithiasis, colon cancer, right-sided colon cancer