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Individualized In-Vitro Fertilization : delivering precision fertility treatment / edited by Human M. Fatemi, Barbara Lawrenz

"Despite the notion that the first baby, Louise Brown, was born in 1978 following IVF performed in a natural menstrual cycle, ovarian stimulation became the golden standard of care in clinical IVF, since the number of oocytes retrieved, is directly associated with pregnancy and life birth rates. The aim should be to titrate the stimulation in such a way that the optimal number of follicles develop. Too few follicles (also referred to as low response) usually means poor IVF outcome, whereas too many developing follicles induce a risk for developing OHSS and possibly reduce the chance of success with increasing number of oocytes, if stimulation is not adjusted towards the end of follicular phase"