Tesis

Faktor-Faktor yang Berhubungan dengan Cakupan Vaksinasi COVID- 19 Dosis Pertama pada Pasien Autoimun = Factors Related to The Uptake of First-Dose COVID-19 Vaccination in Autoimmune Patients.

Latar Belakang. Pasien autoimun rentan terhadap infeksi COVID-19 dan luaran COVID-19 yang lebih berat, sehingga penting untuk mendapat vaksinasi. Namun, terdapat kekhawatiran efek samping, kekambuhan penyakit, serta efektivitas dan imunogenisitas vaksin. Belum ada studi yang meneliti cakupan vaksin COVID-19 pada pasien autoimun di Indonesia. Tujuan. Studi ini bertujuan untuk mengetahui cakupan vaksinasi COVID-19 di Poli Alergi Imunologi RSCM dan faktor – faktor yang berhubungan. Metode. Studi berdesain potong lintang ini melibatkan 260 pasien autoimun dari Poli Alergi Imunologi RSCM periode Juli-Agustus 2023. Pengambilan data menggunakan kuesioner. Analisis bivariat dengan Uji ChiSquare atau Fischer dan analisis multivariat dengan regresi Poisson. Hasil. Cakupan vaksinasi COVID-19 pasien autoimun untuk dosis pertama, dosis kedua, dan dosis ketiga sebesar 60%, 57.3%, dan 40% secara berurutan. Melalui analisis bivariat, didapatkan faktor yang berhubungan dengan cakupan berupa pekerjaan tenaga kesehatan (PR 1,68, p < 0,001), rekomendasi dokter yang merawat (PR 6,47, p < 0,001), dan skala persepsi pasien terhadap keparahan penyakit (p < 0,001). Analisis multivariat menunjukkan hubungan antara rekomendasi dokter yang merawat (PR 4,67, p < 0,001), pekerjaan tenaga kesehatan (PR 1,56, p=0,01), diagnosis SLE (PR 0,81, p=0,003) dan skala persepsi pasien terhadap keparahan penyakit (PR 0,88, p < 0,001). Simpulan. Cakupan vaksinasi COVID-19 pada pasien autoimun di Poli Alergi-Imunologi RSCM adalah 60%. Studi ini menemukan hubungan antara cakupan vaksinasi dengan rekomendasi dokter yang merawat, pekerjaan sebagai tenaga kesehatan, diagnosis SLE, dan persepsi pasien terhadap keparahan penyakit.
Kata Kunci: Cakupan, vaksinasi COVID-19, autoimun


Background. Autoimmune patients are susceptible to COVID-19 infection and more severe COVID-19 outcomes, so it is important to receive vaccination. However, there are concerns about side effects, disease recurrence, as well as vaccine effectiveness and immunogenicity. There has been no research examining the uptake of the COVID-19 vaccine in autoimmune patients in Indonesia. Objectives. The aim of this study is to determine COVID-19 vaccination uptake in autoimmune patients in Allergy Immunology Clinic Cipto Mangunkusumo Hospital (RSCM) and its’ associated factors. Methods. This cross-sectional study involved 260 autoimmune patients from the RSCM Allergy Immunology Clinic for the period July-August 2023. Data collection used a questionnaire. Bivariate analysis with Chi-Square or Fischer Test and multivariate analysis with Poisson regression. Result. COVID-19 vaccination coverage for autoimmune patients for the first, second, and third dose was 60%, 57.3%, and 40%, respectively. Through bivariate analysis, factors related to vaccination uptake were healthcare workers (PR 1,68, p < 0.001), the treating doctor's recommendation (PR 6,47, p < 0.001), and the patient's perception of disease severity (p < 0.001). Multivariate analysis showed an association between the treating physician's recommendation (PR 4.67, p < 0.001), occupation as health care workers (PR 1.56, p=0.01), SLE diagnosis (PR 0.81, p=0.003) and the patient's perception scale of disease severity (PR 0.88, p < 0.001).Conclusion. COVID-19 vaccination uptake in autoimmune patients in Allergy Immunology Clinic RSCM was 60%. The study reported the uptake is associated with physician recommendation, occupation as health care workers, SLE diagnosis, and patients’ perception of the severity of their condition.
Keywords: Uptake, COVID-19 vaccination, autoimmune