Tesis

Efektivitas Dekstrose 40% Gel Untuk Tata Laksana Hipoglikemia Neonatal Transien Asimptomatik Pada Bayi Risiko Tinggi = Effectiveness of Dextrose 40% Gel for the Management of Asymptomatic Transient Neonatal Hypoglycemia in High Risk Infants.

Latar belakang: Hipoglikemia neonatal (HN) merupakan salah satu gangguan metabolik yang sering terjadi pada beberapa hari pertama kehidupan dan salah satu penyebab potensial terjadinya cedera otak dan kematian neonatal yang dapat dicegah. Terapi potensial yang sedang banyak diteliti saat ini adalah penggunaan dekstrose 40% gel untuk terapi hipoglikemia neonatal transien asimptomatik karena bahannya murah, mudah didapat dan tidak invasif. Tujuan: Untuk mengetahui efektifitas pemberian dektrose 40% gel untuk tata laksana HN transien asimptomatik pada bayi risiko tinggi. Metode: Uji klinis acak terkontrol tersamar tunggal dilaksanakan pada bulan April – Agustus 2023. Kriteria inklusi adalah bayi usia gestasi > 34 minggu dan berat badan lahir >1500 gram dengan kadar gula darah 27 – 34 weeks of gestational age and birth weight > 1500 grams with blood sugar levels of 27 – < 47 mg/dL and no symptoms. Block randomization was carried out on 60 samples that met the inclusion and exclusion criteria, divided into 2 groups, the standard therapy group and the treatment group. Results: The incidence of asymptomatic transient NH in this study was 13.2%. The success rate for treating asymptomatic transient NH with 40% dextrose gel was 93.3% with a relative risk reduction (RRR) value of 86.6% and a number need to treat (NNT) of 2.3. There was a significant difference in the average blood sugar level when measured 30 minutes after intervention in the 40% dextrose gel therapy group (74.10 mg/dL) and the standard therapy group 54.83 mg/dL (p < 0.0001). Conclusion: The effectiveness of dextrose 40% gel therapy as an additional therapy is superior to standard therapy in reducing the failure rate of therapy for management asymptomatic transient NH in high risk babies. The mean increase in GD levels in the 40% dextrose gel group was higher compared to the standard therapy group for the management of asymptomatic transient NH in high risk infants.
Keywords: Asymptomatic transient neonatal hypoglycemia, dextrose 40% gel