Skripsi

Hubungan Antara Karakteristik Klinis Pasien Kanker Ginekologi dengan COVID-19 Terhadap Tingkat Mortalitas di Rumah Sakit Dr. Cipto Mangunkusumo Tahun 2020-2022 = Relationship Between Clinical Characteristics of Gynecological Cancer Patients and COVID-19 Against Mortality Rates at Dr. Cipto Mangunkusumo in 2020-2022.

Latar Belakang COVID-19 telah mempengaruhi seluruh aspek kehidupan termasuk dalam bidang kesehatan. Disisi lain, terdapat peningkatan angka kejadian kanker setiap tahunnya. Pasien kanker ginekologi dengan infeksi COVID-19 memiliki tingkat mortalitas yang lebih tinggi. Dengan demikian penelitian ini bertujuan untuk mengetahui karakteristik klinis kanker ginekologi dengan infeksi COVID-19 mana yang paling berpengaruh dengan tingkat mortalitas. Metode Metode yang akan digunakan didalam penelitian ini adalah deskritif dengan pendekatan retrospective cross-sectional Hasil karakteristik klinis yang memiliki hubungan signifikan dengan mortalitas pada pasien kanker ginekologi dengan infeksi COVID-19 adalah ARDS (OR, 48.796; CI 95%, 1.131- 2105.921; P=0.043), Hiperkalemia(OR, 10.960; CI 95% 1.462-82.187; p= 0.020), Sepsis(OR, 18.087; CI 95% 2.192-149.271; P= 0.007), ECOG >2 (OR, 12.629; CI 95% 2.538-62.854; P= 0.002), dan Derajat COVID-19 Berat-Kritis(OR, 108.771; CI 95% 3.917-3020.095; P= 0.006). Kesimpulan Tingkat insidensi pasien kanker ginekologi dengan infeksi COVID-19 2020-2022 Indonesia sebesar 154 per 100.000, serta didapatkan anemia sebagai karakteristik klinis utama, dan karakteristik klinis yang memiliki hubungan signifikan dengan mortalitas pada pasien kanker ginekologi dengan infeksi COVID-19 adalah ARDS (OR, 48.796; CI 95%, 1.131-2105.921; P=0.043), Hiperkalemia(OR, 10.960; CI 95% 1.462-82.187; p= 0.020), Sepsis(OR, 18.087; CI 95% 2.192-149.271; P= 0.007), ECOG >2 (OR, 12.629; CI 95% 2.538-62.854; P= 0.002), dan Derajat COVID-19 Berat-Kritis(OR, 108.771; CI 95% 3.917-3020.095; P= 0.006).
Kata Kunci: COVID-19, Kanker Ginekologi, Karakteristik klinis, Mortalitas


Introduction COVID-19 has affected all aspects of life including the health sector. On the other hand, there is an increase in the incidence of cancer every year. Gynecological cancer patients with COVID-19 infection have a higher mortality rate. Thus this study aims to determine which clinical characteristics of gynecological cancer with COVID-19 infection have the most influence on the mortality rate. Method The method to be used in this study is descriptive with a cross-sectional retrospective approach Results Clinical characteristics that have a significant relationship with mortality in gynecological cancer patients with COVID-19 infection are ARDS (OR, 48.796; CI 95%, 1.131- 2105.921; P=0.043), Hyperkalemia (OR, 10.960; CI 95% 1.462-82.187; p= 0.020), Sepsis (OR, 18,386; CI 95% 2,220-152.253; P= 0.007), ECOG >2 (OR, 12.629; CI 95% 2.538- 62.854; P= 0.002), and Degree of Severe-Critical COVID-19 (OR, 108.771; CI 95% 3.917-3020.095; P= 0.006). Conclusion The incidence rate of gynecological cancer patients with COVID-19 infection in Indonesia for 2020-2022 was 154 per 100,000, and anemia was found as the main clinical characteristic, and clinical characteristics that had a significant relationship with mortality in gynecological cancer patients with COVID-19 infection were ARDS (OR, 48.796; CI 95%, 1.131-2105.921; P=0.043), Hyperkalemia (OR, 10.960; CI 95% 1.462-82.187; p= 0.020), Sepsis (OR, 18,386; CI 95% 2,220-152.253; P= 0.007), ECOG >2 (OR, 12.629; CI 95% 2.538-62.854; P= 0.002), and Degree of Severe-Critical COVID-19 (OR, 108.771; CI 95% 3.917-3020.095; P= 0.006).
Keywords: Clinical Characteristics, COVID-19, Gynecological Cancer, Mortality