Tesis

Lower urinary tract symptoms in anuric and non-anuric adult patients after renal transplantation A comparative study = Studi Komparatif gejala saluran kemih bagian bawah pada pasien dewasa anurik dan non-anurik setelah transplantasi ginjal.

Introduction: A defunctionalized bladder before renal transplantation (RT) might lead to the development of low capacity and poorly compliant bladder. The purpose of this study is to examine the difference of lower urinary tract (LUT) symptoms in anuric and non-anuric individuals after RT. Methods: LUT function and symptoms were assessed in subjects who had undergone RT at Cipto Mangunkusumo Hospital, Jakarta, Indonesia from November 2016 to June 2017. Subjects were divided into anuric and non-anuric groups. We excluded patients with surgical complications that could not undergo uroflowmetry. Results: Thirty-two (21 male, 11 female) subjects were recruited in this study. The anuric subjects were younger than the non-anuric ones (47 ± 12.82 vs. 51.31 ± 16.33, p < 0.001) There were no significant differences in the International Prostate Symptoms Score (IPSS), Overactive Bladder Symptoms Score (OABSS), maximum urinary flow rate (Qmax), post-void residual (PVR) and voided volume between anuric and non-anuric subjects (6.5 ± 3.67 vs. 6.25 ± 2.95, p = 0.567; 4.06 ± 2.01 vs 4.12 ± 2.39, p = 1.000; 20.32 ± 9.04 vs. 22.32 ± 10.31, p = 0.956; 41.12 ± 37.63 vs. 47.62 ± 38.63, p = 0.361; 227.88 ± 112.30 vs 251.06 ± 126.75, p = 0.588, respectively). IPSS-voiding symptom, IPSS-storage symptom and OAB symptom did not differ significantly between both groups (p > 0.05). Thirteen (81.3%) and seven (43.8%) subjects of the anuric and non-anuric group were both pleased with their quality of life, respectively. Conclusions: LUT symptoms do not differ between anuric and non-anuric patients. Further studies with prospective design are required to investigate the changes in LUT function and symptoms in anuric and non-anuric patients after renal transplantation.
Keywords: lower urinary tract symptoms, anuria, renal transplantation



Pendahuluan dan tujuan: Kandung kemih yang tidak berfungsi sebelum transplantasi ginjal (RT) dapat menyebabkan pengembangan kapasitas rendah dan kandung kemih yang tidak sesuai. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan gejala saluran kemih bagian bawah (LUT) pada individu anuria dan non-anurik setelah RT Metode: Fungsi dan gejala LUT dinilai pada subjek yang menjalani RT di Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia dari November 2016 hingga Juni 2017. Subjek dibagi menjadi kelompok anurik dan non-anurik. Pasien dengan komplikasi bedah yang tidak dapat menjalani uroflowmetri akan diekslusi. Kesimpulan: Gejala LUT tidak berbeda antara pasien anurik dan non-anurik. Studi lebih lanjut dengan desain prospektif diperlukan untuk mengevaluasi perubahan fungsi dan gejala LUT pada pasien anurik dan non-anurik setelah transplantasi ginjal.
Kata kunci: gejala saluran kemih bagian bawah, anuria, transplantasi ginjal