Tesis

Hubungan Immunoscore terhadap Invasi Limfovaskular dan Stadium Klinis pada Kanker Kolorektal = Association between Immunoscore with Lymphovascular Invasion and Clinical Staging in Colorectal Cancer.

Tujuan: Terlepas dari manfaat prognostik immunoscore yang berfungsi sebagai alat dalam kanker kolorektal, belum ada studi laporan alasan di balik itu. Penelitian ini mencoba untuk mengidentifikasi hubungan immunoscore dan tingkat invasi limfovaskular dan tingkat tahapan klinis pasien kanker kolorektal sebagai mekanisme bagi immunoscore untuk memrediksi hasil dari kanker kolorektal. Pasien dan metode: Ini adalah korelasi dengan studi cross-sectional yang menganalisis data riwayat kesehatan dan hasil laboratorium. Immunoscore dikumpulkan dari laboratorium independen, dan data lain (gender, usia, diagnosis, lokasi tumor, invasi limfovaskular) diambil dari catatan medis dari Rumah Sakit Swasta catatan kanker kolorektal. Pengumpulan data dilakukan sejak Oktober hingga Desember 2022. Analisis data dilakukan dengan uji statistic Chi-Square dengan p < 0.05. Hasil: Hasilnya menunjukkan mayoritas subjek dengan lokasi tumor di rektosigmoid (25%) dan tahap lanjut (65%) dengan adanya invasi limfovaskular temuan (80%). Uji statistik Chi-Square menunjukkan hasil dari p = 0,025 dan p = 0.64, masing-masing, invasi limfovaskular invasi dan tahapan klinis. Kesimpulan: Penelitian ini menunjukkan bahwa immunoscore memiliki hubungan dependen dengan tingkat kejadian invasi limfovaskular dan hubungan independent dengan tahapan klinis TNM pada pasien kanker kolorektal. Aplikasi dan penggunaan immunoscore yang bermanfaat bagi klinisi untuk memberikan saran dan pengertian ke pasien tentang pilihan terapi mereka juga hasil bagi pasien.



Purpose: Despite the immunoscore benefit function as a prognostic tool in colorectal cancer, no study reports the reason behind it. This study tried to identify the relationship between the immunoscore and the incidence of lymphovascular invasion and clinical stage in colorectal cancer patients as a mechanism for immunoscore to predict the outcome of colorectal cancer. Patients and methods: This is correlational with a cross-sectional study that analyzed medical record data and laboratory results. Immunoscore was collected from an independent private laboratory, and other data (gender, age, diagnosis, tumor location, lymphovascular invasion) were from medical records from the Private Hospital colorectal cancers registry. Data collection was carried out from October 2022 to December 2022. Data analysis was performed with the Chi-Square statistical test with a significant p < 0.05. Results: The results showed the majority of subjects had tumor locations in the rectosigmoid (25%) and advanced stages (65%) with lymphovascular invasion findings (80%). Chi-Square statistical test shows the result of p = 0,025 and p = 0.64, respectively, lymphovascular invasion and clinical staging. Conclusion: This study shows that the immunoscore has a dependent relationship with the incidence of lymphovascular invasion and an independent relationship with the clinical stage of TNM in colorectal cancer patients. The application and use of immunoscore are beneficial for clinicians to give suggestions and understanding to patients about their choice of therapy also outcome for the patient.