Tesis

Profil Kadar Asam Serum dan Hubungannya dengan Resistensi Insulin pada Anak Kandung Penyandang DM Tipe 2 = Serum Uric Acid Profile and Correlation with Insulin Resistance in The First-Degree Relatives of Patients with Type 2 Diabetes Mcllitus.

Latar belakang. Studi sebelumnya menunjukkan bahwa hiperurisemia mengambtl bagian dalam berkonttibust dalam berkontribusi pada proses sindrom metabohk dua arah. Hiperurisemia merupakan kelainan me1abolisme asam urat yang menghasilkan kondisi SUA yang berlebihan datam plasma darah sebagai akibat dari degradasi metabolisme purin. Namun, masih ada penelitian SUA dan sindrom meiabolik yang langka pada subjek dewasa muda dan tidak acla penelitian yang pemah d1lakukan pada FDR dewasa muda dari subjek T2DM sejauh ini secara lokal dan mtemasional. Untuk mengetahui perbedaan kadar asam urat serum (SUA) antara derajat-kerahat penama (FDR) diabetes melirus tipe 2 (TIDM) dan non-FDR T2DM, sena korelasinya dengan resrstensr msuhn pada FDR T2DM. Metode. Sebanyak 126 (62 FDR dan 64 non-FDR, berusia 25-39 tahun) mata pelajaran terdaftar. lndeks massa tubuh, lmgkar pmggang, tekanan darah, glukosa plasma puasa, profit lipid dan kadar SUA dmkur. Subjek dengan gangguan 1oleransi gluk:osa dan htpenenst udak tennasuk:. Hiperunsemta dldefimstkan oleh American College of Rheumatology � 7,0 mg/dL unruk pria dan 2:: 6,5 mg/dL unruk wanna), resistensi insulin didefintsLk:an oleh Homeostatic Model Assessment for lnsulm Resistance (HOMA-IR). HasU. Sebanyak 126 subJek yang memenuhi kriteria inldusi. Kami udak meoemuk:an perbedaan yang signifikan dalam karakteristik dasar kelompok FDR dan non FDR dan kelompok T2DM. Tingkat SUA tidak berbeda antara FDR dan non-FDR T2DM (5,75 1,41 mg/dL dan 5,54 1,80 = mg/dL, p 0,287). Tidak ada korelasi aruara SUA dan resaenst insulin pada FDR T2DM (r = 0.208. p = 0,105). Kesimpulan. Tingkai: SUA dalam normoglikemia clan normo1ensi FDR T2DM tidak berbeda dibandingkan dengan non-FDR T2DM. Tidak ada korelasi antara SUA clan resistensi insulin pada orang dewasa muda yang sehat dari FDR T2DM
Kata kunci. resistensi insulin, asam urat, kerabat 1ingkat penama, diabetes mellitus tipe 2, sindrom metabolik


Background. Previous studies showed that hyperuricemia takes part in contributing the process of metabolic syndrome bidirectionally. Hyperuricemia is an abnormality of uric acid metabolism which produce a condition of excessive SUA in blood plasma as a result of degradation from purine metabolism. However, there is still scarce research ofSUA and metabolic syndrome on young adult subjects and no study has ever done in young adult FDR ofT2DM subjects so far locally and internationally. To determine difference of serum uric acid (SUA) level between first degree-relatives (FDR) of type 2 diabetes mellirus (T2DM) and non-FDR ofT2DM, and its correlation with insulin resistance in FDR ofT2DM. Methods. A total of 126 (62 FDR and 64 non-FDR, aged 25-39 years) subjects were enrolled. Body mass index, waist circumference, blood pressure, fasting plasma glucose, lipid profile and SUA levels were measured. Subjects with impaired glucose tolerance and hypenension were excluded. Hyperuricemia was defined by American College ofRheumatology (?: 7.0 mgldL for males and 2: 6.S mg/dL for females), insulin resistance was defined by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Results. There were 126 subject met inclusion critena. We discovered no significant differences in basic characteristics of both FDR and non FDR ofT2DM groups. SUA level was not different between FDR and non-FDR ofT2DM (5.75±1.41 mgldL and 5.54±1.80 = mgldL, p was 0.287). There no correlation between SUA and msulm resistance in FDR of = = T2DM (r 0.208, p 0.105). Conclusions. SUA level in normoglycemia and normotensive FDR ofT2DM was not different compared to non-FDR ofTIDM. There was no correlation between SUA and insulin resistance in healthy young adults of FDR ofT2DM.
Keywords. insulin resistance, uric acid, first-degree relatives, type 2 diabetes mellirus, metabolic syndrome