Tesis

Pengaruh Chemotherapy-Induced Nausea and Vomiting terhadap Kualitas Hidup Pasien Kanker Ovarium di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo = The Correlation between Chemotherapy-Induced Nausea and Vomiting with Quality of Life in Ovarian Cancer Patient at Dr. Cipto Mangunkusumo National Central Public Hospital.

Latar Belakang: Pengobatan kanker ovarium dengan kemoterapi carboplatin dan paclitaxel memiliki efek samping non hematologi berupa mual-muntah (9-10%) yang memberikan dampak negative terhadap kualitas hidup pasien. Tujuan penelitian ini adalah untuk mengetahui pengaruh Chemotherapy-Induced Nausea and Vomiting (CINV) terhadap kualitas hidup pasien kanker ovarium dalam kemoterapi regimen lini pertama carboplatin dan paclitaxel di RSUPN Dr. Cipto Mangunkusumo (RSCM). Metode: Penelitian ini dilakukan secara deskriptif analitik dengan menggunakan desain potong lintang dengan subyek penelitian pasien kanker ovarium dalam kemoterapi regimen lini pertama carboplatin dan paclitaxel yang memenuhi kriteria inklusi di RSCM. Kami melakukan pengajuan kuesioner European Organization for Research and Treatment of Cancer (EORTC) QLQ-OV28 versi Bahasa Indonesia dan melakukan studi pendahuluan. Selanjutnya dilakukan pengisian kuesioner tersebut bersama kuesioner EORTC QLQ-C30 versi Bahasa Indonesia oleh pasien sebelum kemoterapi dan satu minggu sesudah kemoterapi. Hasil: Terbentuknya kuesioner EORTC QLQ-OV28 versi Bahasa Indonesia pada penelitian tahap pertama. Pada penelitian tahap kedua didapatkan peningkatan beberapa skala gejala dan penurunan skala fungsi. Dari 40 subjek penelitian terdapat peningkatan 72,5% skala gejala mual dan muntah (NV) dan 67,5% penurunan skala kualitas hidup (QOL) pada pasien setelah dilakukan kemoterapi. Secara parsial CINV berpengaruh signifikan terhadap penurunan QOL (nilai sig 0,047 dan y=12,208-0,432). Kesimpulan: CINV merupakan salah satu skala gejala yang berpengaruh besar dalam menurunkan kualitas hidup pasien kanker ovarium yang menjalani kemoterapi regimen lini pertama carboplatin dan paclitaxel di RSCM.
Kata kunci: Chemotherapy-Induced Nausea and Vomiting (CINV), kualitas hidup, EORTC QLQ-OV28, EORTC QLQ-C30


Background: Treatment of ovarian cancer with chemotherapy carboplatin and paclitaxel has non-haematological side effects in nausea and vomiting (9-10%) which have a negative impact on the patient's quality of life. The aim of this study is to determine the effect of Chemotherapy-Induced Nausea and Vomiting (CINV) on the quality of life of ovarian cancer patients in the first-line chemotherapy regimen of carboplatin and paclitaxel at Dr. Cipto Mangunkusumo National Cental Public Hospital (RSCM). Methods: We conducted analytical descriptive study using a cross-sectional design in ovarian cancer patients at first-line chemotherapy regimens of carboplatin and paclitaxel who are included in inclusion criteria in RSCM. We submitted the European Organization for Research and Treatment of Cancer (EORTC) QLQOV28 in Indonesian version and conducted a preliminary study. Subsequently, the patient filled out that questionnaire and the EORTC QLQ-C30 questionnaire in Indonesia version before chemotherapy and one week after chemotherapy. Results: The Indonesian version of the EORTC QLQ-OV28 questionnaire was formed in the first phase of the research. We found that several symptom scales increased and function scales decreased. From 40 subjects we found 72.5% had increase in the nausea and vomiting (NV) symptom scale and 67.5% had decrease in the quality of life (QOL) scale in patients after chemotherapy. Partially CINV had a significant effect on the decrease in QOL (sig value 0.047 and y=12,2080.432). Conclusion: CINV is a symptom scale that has a major influence in reducing the quality of life of ovarian cancer patients undergoing first-line chemotherapy regimens of carboplatin and paclitaxel in RSCM.
Keywords: Chemotherapy-Induced Nausea and Vomiting (CINV), quality of life, EORTC QLQ OV28, EORTC QLQ-C30