Tesis

Occupational Stress and Its Relation to Graves’ Disease: An Evidence-Based Case Report = Stress Kerja dan Hubungannya dengan Penyakit Grave’s: Laporan Kasus Berbasis Bukti.

Background: Graves’ disease is an autoimmune thyroid gland disease that causes increased activity of the thyroid hormones. But, the mechanism by which the autoantibodies are generated is still unclear. Some theory suggests that daily life stress may be a risk factor that triggers Graves’ disease. The aim of this report is to systematically searching the risk factor of the Graves disease and the evidence on relationship with the occupational stress. Methods: In this case report, a 47-year-old career woman with prominent occupational stress was diagnosed with Graves’ disease. Literature searching was done on database such as Pubmed, Cochrane Library, and Science Direct with occupational stress, stressful life event, and Graves’ disease as the keywords. One article was selected and critically appraised. Results: One case-control study showed that patients with Graves’ disease had odds ratio (OR) of having stressful life events as big as 8.59 (95%CI = 2.35-20.80), and the number needed to harm (NNH) is 2.35. Conclusion: Occupational stress is a prominent risk factor for developing Graves’ disease. However, this is based on one article
Keywords: Graves’ disease, occupational stress


Latar Belakang: Penyakit Graves merupakan penyakit autoimun pada kelenjar tiroid yang menyebabkan peningkatan aktivitas hormon tiroid. Namun, mekanisme mengenai bagaimana autoantibodi tersebut terbentuk belumlah jelas. Beberapa teori menyakan bahwa stress pada kehidupan sehari-hari dapat menjadi faktor risiko yang mencetuskan terjadinya penyakit Graves. Metode: Pada laporan kasus ini, seorang wanita pekerja berusia 47 tahun dengan stress okupasi yang prominen didiagnosis dengan penyakit Graves. Pencarian literatur dilakukan pada database Pubmed, Cochrane, dan Science Direct dengan menggunakan kata kunci occupational stress, stressful life event, dan Graves’ disease. Pencarian menghasilkan satu artikel terpilih yang kemudian ditelaah kritis. Hasil: Satu studi kasus-kontrol menunjukkan bahwa pasien dengan penyakit Graves mempunyai odds ratio (OR) untuk mengalami kejadian stress dalam kehidupan sebesar 8.59, sedangkan number needed to harm (NNH) yang diperoleh sebesar 2,35. Kesimpulan: Stress okupasional merupakan faktor risiko yang penting dalam menyebabkan penyakit Graves.
Kata Kunci: penyakit Graves, stress Okupasi