Tesis

Korelasi Calcium Score Arteri Koroner dengan Calcium Score Katup Aorta dan Mitral pada Pasien dengan Atherosklerosis Arteri Koroner = Correlation Between Coronary Artery Calcium Score with Aortic and Mitral Valve Calcium Score in Patients with Coronary Atherosclerosis.

Latar belakang: Kalsifikasi arteri koroner didasari oleh proses atherosklerosis dan dapat dievaluasi secara kuantitatif dengan calcium score. Kalsifikasi dapat pula terjadi di katup aorta dan mitral. Patofisiologi kalsifikasi katup aorta-mitral memiliki kemiripan dengan atherosklerosis arteri koroner, namun hubungan antara ketiganya belum jelas, khususnya pada pasien yang sudah mengalami atherosklerosis arteri koroner dan pasien etnis Asia. Penelitian ini bertujuan mengetahui korelasi calcium score arteri koroner dengan calcium score katup aorta dan mitral pada pasien dengan atherosklerosis arteri koroner di Indonesia. Metode: Studi korelasi, desain cross-sectional. Dilakukan stratified randomization pada sampel yang memenuhi kriteria inklusi berdasarkan kategori calcium score arteri koroner. Dilakukan pengukuran calcium score arteri koroner, katup aorta dan mitral secara semiautomatis, kemudian dilakukan uji korelasi antara ketiga variabel tersebut. Hasil: Terdapat 97 subjek (kategori calcium score arteri koroner “rendah” 34 subjek, “sedang” 30 subjek, “tinggi” 33 subjek) dengan rerata usia 63,85 (+ 9,80) tahun. Median calcium score arteri koroner 158,7 AU (1 – 3917,7 AU), katup aorta 12,6 AU (0 – 3747 AU) dan katup mitral 0,1 AU (0 – 1247,5 AU). Terdapat korelasi yang sangat lemah antara calcium score arteri koroner dengan calcium score katup aorta dan calcium score katup mitral. Kesimpulan: Tidak terdapat korelasi yang bermakna secara statistik antara calcium score arteri koroner dengan calcium score katup aorta dan calcium score katup mitral pada pasien dengan atherosklerosis arteri koroner di Indonesia. Perlu dilakukan penelitian lebih lanjut untuk mengevaluasi faktor-faktor lain yang mungkin berpengaruh terhadap kalsifikasi katup aorta dan mitral.
Kata kunci : atherosklerosis, arteri koroner, calcium score, katup aorta, mitral.


Background: Coronary artery calcification is caused by atherosclerosis, which can be evaluated quantitatively using calcium score. Aortic and mitral valve can also calcify. Pathophysiology of aortic-mitral valve calcification has several similarities with coronary atherosclerosis, but their correlation has not been clear, especially in coronary atherosclerosis patients of Asian ethnicity. This study aims to investigate the correlation between calcium score of coronary artery and calcium score of aortic and mitral valve in Indonesians with coronary atherosclerosis. Methods: Cross-sectional, correlation study. Stratified randomization was done based on the coronary artery calcium score category. Calcium score was calculated semi-automatically. Correlation test was done between coronary artery calcium score and aortic valve calcium score, coronary artery calcium score and mitral valve calcium score. Results: Ninety-seven subjects (coronary calcium score “mild” 34 subjects, “moderate” 30 subjects, “severe” 33 subjects) with mean age 63.85 (+ 9.80) years old. Median coronary artery calcium score was 158.7 AU (1 – 3917.7 AU), aortic valve 12.6 AU (0 – 3747 AU) and mitral valve 0.1 AU (0 – 1247.5 AU). There was a very weak correlation between calcium score of coronary artery and calcium score of aortic valve, as well as calcium score of mitral valve. Conclusion: There was no statistically significant correlation between calcium score of coronary artery and calcium score of aortic valve, as well as calcium score of mitral valve in Indonesian patients with coronary atherosclerosis. Further studies are needed to evaluate other factors which may contribute to aortic and mitral valve calcification.
Keywords: aortic valve, atherosclerosis, calcium score, coronary artery, mitral valve.