Tesis

Hubungan Rasio Asupan Asam Lemak Omega-3/Omega-6 dengan Selera Makan yang Dimediasi oleh Tumor Necrosis Factor-Alpha pada Penyandang Multidrugs Resistant Tuberkulosis Paru = The Relationship between Ratio Omega-3/Omega-6 Fatty Acid Intake and Appetite Mediated by Tumor Necrosis Factor-Alpha in Pulmonary Multidrugs Resistant Tuberculosis.

Kadar TNF-α didapatkan jauh lebih tinggi pada penderita MDR-TB dibandingkan dengan penderita TB sensitif obat, TNF-α dinyatakan sebagai salah satu sitokin proinflamasi yang dapat menekan selera makan. Asam lemak omega-3 diketahui memiliki efek antiinflamasi, namun efek terhadap selera makan masih menunjukkan hasil beragam, penelitian mengenai asupan asam lemak omega3/omega-6 yang dapat mendukung selera makan pada penderita MDR-TB belum pernah dilakukan. Penelitian ini dilakukan untuk mengetahui hubungan antara rasio asupan asam lemak omega-3/omega-6 dengan selera makan yang dimediasi oleh TNF-α pada pasien MDR-TB paru. Penelitian potong lintang ini dilakukan kepada 46 subyek laki-laki dan perempuan dewasa penderita MDR-TB yang sedang menjalani terapi fase intensif. Data dikumpulkan melalui kuesioner, food recall 1x24 jam, pengukuran antropometri dan pengambilan darah vena. Analisis korelasi menggunakan uji pearson dan spearman. Rasio asupan asam lemak omega3/omega-6 yang didapatkan adalah 0,11±0,05, nilai tengah TNF-α 7,49(1,66447,62) pg/ml dan rerata selera makan 58,72±26,7. Hasil penelitian ini menunjukkan tidak terdapat hubungan antara rasio asupan asam lemak omega3/omega-6 dan TNF-α (r=0,16; p=0,91), terdapat hubungan positif antara TNF-α dengan selera makan (r=0,31; p=0,04), serta tidak terdapat hubungan antara rasio asupan asam lemak omega-3/omega-6 dengan selera makan (r=-0,1; p=0,54) pada penderita MDR-TB paru.
Kata kunci: TNF-α, MDR-TB, Omega-3/omega-6, selera makan


TNF-α levels were found to be much higher in MDR-TB patients compared to drugsensitive TB patients, TNF-α is stated as one of the pro-inflammatory cytokines that can suppress appetite. Omega-3 fatty acid are known to have anti-inflammatory effects, but the effects towards appetite are still conflicting, research on the intake of omega-3 / omega-6 fatty acid which can support appetite in patients with MDRTB has never been done. This study was conducted to determine the relationship between ratio of omega-3 / omega-6 fatty acid intake and appetite mediated by TNF-α in pulmonary MDR-TB. This cross-sectional study was conducted on 46 adult male and female subjects with MDR-TB who were undergoing intensive phase therapy. Data were collected through questionnaires, 1x24 hours food recall, anthropometric measurements and venous blood collection. Correlation analysis used pearson and spearman test. The ratio of omega-3 / omega-6 fatty acid intake is 0.11±0.05, median value of TNF-α 7.49(1.66-447.62) pg/ml and average of appetite 58.72±26.7. In conclusion, there is no relationship between the ratio of omega-3 / omega-6 fatty acid intake and TNF-α (r=0,16; p=0,91), there is correlation between TNF-α and appetite (r=0.31; p=0.04), and there is no relationship between the ratio of omega-3 / omega-6 fatty acid intake with appetite (r=-0,1; p=0,54) in patients with pulmonary MDR-TB.
Keywords: TNF-α, MDR-TB, Omega-3/omega-6, appetite