Tesis

Uji Validitas dan Reliabilitas Kuesioner Multiple Scelrosis Quality of Life-54 Versi Bahasa Indonesia (MSQOL-54 INA) = Validation of the Indonesian version of Multiple Sclerosis Quality of Life (MSQOL-54 INA) Questionnaire.

Latar belakang: Penilaian kualitas hidup pasien multipel sclerosis (MS) belum rutin digunakan di Indonesia karena belum terdapatnya kuesioner spesifik berbahasa indonesia yang valid. Tujuan dari penelitian ini adalah untuk adaptasi lintas budaya dan validasi kuesioner kuesioner MSQOL-54 versi Indonesia (MSQOL-54 INA). Metode: Adaptasi lintas budaya dilakukan sesuai dengan metode forwardbackward terstandar. Uji psikometri dilakukan dengan menilai reliabilitas (α Cronbach), validitas interna (item internal consistency, item discriminant validity dan analisis fakorial) dan validitas eksterna dengan menilai korelasi dengan faktor klinis EDSS dan faktor demografis lainnya. Hasil: Uji reliabilitas α Cronbach menunjukkan konsistensi internal yang baik ( > 0,7) di setiap domain kecuali domain persepsi kesehatan (0,665) dan fungsi sosial (0,433). Validitas bentuk dengan komputasi koefisien korelasi menunjukkan konsistensi konsistensi internal yang sesuai dengan dimensi MSQOL-54 asli. Berdasarkan analisis faktorial domain energi, keterbatasan peran akibat masalah emosional, fungsi sosial dan persepsi kesehatan tidak sesuai dengan dimensi asli. Validitas eksternal dengan EDSS menunjukkan korelasi negatif pada semua domain kecuali fungsi seksual, kemaknaan yang signifikan secara statistik ditemukan pada kedua skor komposit. Kesimpulan: Kuesioner MSQOL-54 INA memilki reliabilitas yang baik dan terbukti valid serta dapat diterima dengan baik oleh pasien MS di Indonesia. Selanjutnya kuesioner ini dapat digunakan oleh klinisi indonesia untuk tata laksana MS yang lebih komprehensif.
Kata kunci: multipel sklerosis, kualitas hidup, MSQOL-54, validasi


Background: Quality of life assessment of patients with multiple sclerosis (MS) is not routinely performed in Indonesia due to the unavailability of the validated Indonesian version of a specific instrument. The objective of this study was to transculturally adapt and validate the Indonesian version of the MSQOL-54 (MSQOL-54 INA) questionnaire. Methods: The transcultural adaptation was conducted by performing a standardized forward-backward method. Psychometric analysis was performed by assessing the reliability (Cronbach α), internal validation (item internal consistency, item discriminant validity and factorial analysis) and external validation by measuring the correlation with a clinical factor such as EDSS and other demographic factors. Results: Reliability test with Cronbach α showed good internal consistency ( > 0.7) at each domain, except for health perception (0.665) and social function (0.433). Construct validity using computation of correlation coefficient showed internal consistency in accordance with the original MSQOL-54 standard dimension. Factorial analysis showed that energy, role limitation due to emotional problems, social function and health perception is not in accordance with the original version. External validation with EDSS showed negative correlation on almost all components, except for sexual function, but both composite scores were statistically significant. Conclusion: MSQOL-54 INA questionnaire has good internal reliability and is proven to be valid and well-accepted by Indonesian MS patients. Therefore, it can be used by Indonesian clinicians for more comprehensive MS management.
Keywords: Multiple Sclerosis, Quality of Life, MSQOL, validation