Skripsi

Hubungan Antara Reseptor Hormonal dan Protein HER2 terhadap Jenis Metastasis Kanker Payudara = Association of Hormone Receptor and HER2 protein with The Types of Breast Cancer Metastases .

Latar Belakang: Kanker payudara merupakan kanker dengan insidensi tertinggi kedua di dunia pada tahun 2018. Setiap 100.000 wanita di Indonesia, 40 mengidap kanker payudara. Mortalitas pada kanker payudara paling banyak disebabkan oleh kejadian metastasis organ viseral yang dilaporkan memiliki prognosis lebih buruk dibandingkan metastasis non viseral. Ekspresi reseptor hormonal (HR) dan protein HER2 atau subtipe intrinsik molekular diindikasikan dapat memprediksi jenis atau lokasi metastasis kanker payudara. Karena itu, perlu ada penelitian tentang hubungan HR dan HER2 terhadap jenis metastasis kanker payudara, terutama pada populasi di Indonesia untuk memperkirakan perjalanan penyakit. Tujuan: Mengetahui hubungan antara reseptor hormonal dan HER2 terhadap jenis metastasis kanker payudara, viseral maupun non viseral. Metode: Penelitian dengan desain cross sectional ini menggunakan data dari sembilan puluh satu pasien kanker payudara dengan metastasis yang dipilih dengan cara consecutive sampling dari RSCM dan RS MRCCC Siloam. Status HR dan HER2 diambil dari pemeriksaan imunohistokimia, sedangkan jenis metastasis diambil dari hasil pemeriksaan radiologi atau patologi anatomi. Data diolah dengan uji chi square dan disajikan dalam bentuk tabel. Hasil: Analisis bivariat antara HR dengan metastasis viseral menghasilkan nilai OR 0,549 (95% CI 0,165-1,829), dengan metastasis non viseral OR 1,533 (95% CI 0,565-4,157), dan dengan kedua metastasis viseral dan non viseral OR 0,960 (95% CI 0,351-2,624). Untuk analisis antara protein HER2 dengan metastasis viseral menghasilkan OR 2,333 (95% CI 0,825-6,599), dengan metastasis non viseral OR 0,538 (95% CI 0,223-1,302), dan dengan kedua metastasis viseral dan non viseral OR 1,061 (95% CI 0,442-2,549). Semua analisis menghasilkan p>0,05. Kesimpulan: Tidak ditemukan adanya hubungan yang bermakna antara HR maupun HER2 terhadap jenis metastasis kanker payudara
Kata kunci: Kanker payudara, HER2, Reseptor Hormonal, Metastasis Viseral, Metastasis Non Viseral


Background: Breast cancer is the second highest incidence of cancer in the world in 2018. Every 100,000 women in Indonesia, 40 have breast cancer. Mortality in breast cancer is mostly caused by the incidence of visceral organ metastases that are reported to have a worse prognosis than non-visceral metastases. Expression of hormone receptors (HR) and HER2 protein or molecular intrinsic subtypes can be indicated to predict the types or sites of breast cancer metastases. Therefore, there needs to be a research on the association of HR and HER2 with the types of breast cancer metastases, especially for the populations in Indonesia, to estimate the course of the disease. Objective: To determine the association of hormone receptor and HER2 protein with the types of breast cancer metastases Methods: This cross sectional study sampled ninety one breast cancer patients with metastases selected by consecutive from RSCM and RS MRCCC Siloam. HR and HER2 status were taken from immunohistochemical examination, while the types of metastases were taken from the results of radiological or anatomic pathology examination. Data then processed with chi square test and presented in tables. Results: Bivariate analysis of HR with visceral metastases yielded OR values of 0,549 (95% CI 0,165-1,829), with non-visceral metastases OR 1.533 (95% CI 0.565-4.157), and with both visceral and non-visceral metastases OR 0.960 (95% CI 0.351 -2.624). For the analysis of HER2 protein with visceral metastases yielded OR 2,333 (95% CI 0,825-6,599), with non-visceral metastases OR 0.538 (95% CI 0.223-1.302), and with both visceral and non-visceral metastases OR 1.061 (95% CI 0.442 -2.549). All analyzes have p value > 0.05. Discussion: No significant association was found between HR and HER2 with the types of breast cancer metastasis
Keywords: Breast Cancer, Hormone Receptor, HER2, Visceral Metastases, Non Visceral Metastases