Skripsi

Studi Korelasi antara Kadar Vitamin D dan Glukosa Jaringan Plasenta Preeklamsia pada Usia Kehamilan di Bawah 32 Minggu = Correlation Study between vitamin D and Glucose Levels in Preeclampsia Placenta Tissue at Age of Pregnancy Under 32 Weeks .

Pendahuluan: Di Indonesia, kasus preeklamsia menyebabkan angka mortalitas yang tinggi untuk bayi dan anak, yaitu 40% untuk angka kematian maternal dan 30-50% untuk angka kematian perinatal. Kekurangan vitamin D diduga berpengaruh terhadap patogenesis preeklamsia. Selain itu, vitamin D diketahui berpengaruh terhadap sensitivitas insulin secara linear, namun pernyataan ini masih membutuhkan penelitian lebih lanjut terutama pengaruh vit D pada preeklamsia. Penelitian ini bertujuan untuk membandingkan kadar vitamin D dan kadar glukosa pada jaringan plasenta preeklamsia, khususnya di bawah 32 minggu, untuk melihat pengaruh vitamin D terhadap kadar glukosa jaringan plasenta. Metode: Penelitian ini adalah penelitian analitik dan menggunakan desain potong lintang. Sampel plasenta preeklamsia yang digunakan adalah sampel tersimpan yang diambil dari RSUPN Cipto Mangunkusumo dengan rentang tahun 2016-2017, dengan ijin etik no: 0878/UN2.F1/ETIK/2018. Sampel plasenta preeklamsia berjumlah 10. Kadar vitamin D diukur dengan menggunakan kit Elabscience, sedangkan kadar glukosa diukur dengan menggunakan kit Randox Ransel, dengan metode spektrofotometri. Data yang diperoleh kemudian dianalisis dengan metode Pearson. Hasil: Kadar vitamin D dan kadar glukosa pada jaringan plasenta preeklamsia di bawah 32 minggu berbanding terbalik secara lemah berdasarkan korelasi Pearson (p = -0,180). Akan tetapi, korelasi ini tidak bermakna menurut uji signifikansi 1-tailed (p = 0,310). Kesimpulan: Korelasi vitamin D dan glukosa pada jaringan plasenta preeklamsia di bawah 32 minggu bersifat negatif lemah.
Kata Kunci: Vitamin D, Glukosa, Sensitivitas Insulin, Plasenta, Preeklamsia


Introduction: In Indonesia, cases of preeclampsia cause a high mortality rate for infants and children, which is 40% for the maternal mortality rate and 30-50% for the perinatal mortality rate. Vitamin D deficiency is thought to influence the pathogenesis of preeclampsia. In addition, vitamin D is known to have an effect on insulin sensitivity in a linear manner, but this statement still requires further research, especially the effect of vitamin D on preeclampsia. This study aimed to compare vitamin D levels and glucose levels in preeclampsia placental tissue, especially under 32 weeks, to see the effect of vitamin D on placental tissue glucose levels. Method: This research is an analytical research and uses a cross-sectional design. The preeclampsia placenta sample used was a stored sample taken from Cipto Mangunkusumo Hospital within the year of 2016-2017, with ethical permission no: 0878 / UN2.F1 / ETIK / 2018. The number of the preeclampsia tissue samples is ten. Vitamin D levels were measured using the Elabscience kit, while glucose levels were measured using the Randox Backpack kit, using the spectrophotometric method. The data obtained were then analyzed by the Pearson method. Results: Vitamin D levels and glucose levels in placental tissue of preeclampsia under 32 weeks were inversely proportional (poor) to the Pearson correlation (p = -0.180). However, this correlation was not significant according to the 1-tailed significance (p = 0.310). Conclusion: Correlation of vitamin D and glucose in placental tissue of preeclampsia under 32 weeks is poorly negative.
Keywords: Vitamin D, Glucose, Insulin Sensitivity, Placenta, Preeclampsia