Tesis

Kadar Seng Serum dan Korelasinya dengan Resistensi Insulin pada Ibu Laktasi di Jakarta = Zinc Serum Level and Its Correlation with Insulin Resistance among Lactating Mothers in Jakarta .

Resistensi insulin adalah kondisi yang mendasari terjadinya diabetes melitus. Prevalensi diabetes melitus kian meningkat dari tahun ke tahun, termasuk di Indonesia. Proporsi penderita diabetes melitus ditemukan lebih tinggi pada perempuan. Perubahan fisiologis yang terjadi selama kehamilan merupakan salah satu penyebab terjadinya resistensi insulin dan resistensi insulin ini dapat bertahan hingga masa postpartum. Laktasi serta nutrien salah satunya seng, dapat memengaruhi resistensi insulin. Penelitian dengan desain potong lintang ini bertujuan menilai kadar seng serum dan korelasinya dengan resistensi insulin pada ibu laktasi di Jakarta. Pengambilan subjek dilakukan di Puskesmas Kecamatan Cilincing, Jakarta Utara dan Grogol Petamburan, Jakarta Barat pada bulan FebruariApril 2019. Sebanyak 75 orang ibu laktasi pada 3–6 bulan postpartum yang berusia 20–40 tahun direkrut menjadi subjek penelitian ini. Sekitar 76% (n = 57) subjek memiliki kadar seng rendah dengan rerata sebesar 62,33 ± 11,89 µg/dL. Resistensi insulin dinilai dengan menggunakan HOMA-IR (homeostasis model assessmentinsulin resistance). Median HOMA-IR adalah 0,54 (0,22–2,21). Sebanyak 13,3% (n = 10) subjek diprediksi mengalami resistensi insulin. Dilakukan uji korelasi antara kadar seng serum dengan HOMA-IR. Tidak ditemukan adanya korelasi bermakna antara kadar seng serum dengan HOMA-IR (r = 0,003, p = 0,977).
Kata kunci: Laktasi; HOMA-IR; resistensi insulin; seng


Insulin resistance is a condition that underlies the development of diabetes mellitus. The prevalence of diabetes mellitus keeps rising, including in Indonesia. A higher proportion of diabetes was found in women. Physiological changes during pregnancy can cause insulin resistance that may persist until the postpartum period. Lactation and nutrient like zinc can influence insulin resistance. This crosssectional study aimed to measure the correlation between zinc serum level and insulin resistance of lactating mothers in Jakarta. Subjects recruitment was conducted in Puskesmas Kecamatan Cilincing, North Jakarta and Grogol Petamburan, West Jakarta between February and April 2019. A total of 75 lactating mothers at 3–6 month postpartum aged 20–40 years old were recruited as subjects. Approximately 76% (n = 57) subjects had low serum zinc level with mean value 62,33 ± 11,89 µg/dL. Insulin resistance was assessed using HOMA-IR (homeostasis model assessment-insulin resistance). HOMA-IR median was 0,54 (0,22–2,21). Around 13.3% (n = 10) subjects were predicted to suffer from insulin resistance. Correlation test between serum zinc level and HOMA-IR was done. No correlation was found between serum zinc level and HOMA-IR (r = 0.003, p = 0.977).
Keywords: Lactation; HOMA-IR; insulin resistance; zinc