Skripsi

Rasio Albumin Globulin dan Ekspresi Komplemen C3: Hubungannya pada Populasi Kumuh dan Nonkumuh = Albumin Globulin Ratio and Complement C3 Expression: The Correlation in Slum and Nonslum Population.

Pendahuluan- Penduduk pemukiman kumuh dan nonkumuh memiliki pola pajanan pathogen yang berbeda sehingga diduga menyebabkan perbedaan profil imun. Rasio albumin globulin dan komplemen C3, fraksi β-globulin yang berfungsi sebagai pusat konvergensi sistem komplemen yang merupakan sistem imun bawaan, diduga memiliki profil yang berbeda berdasarkan tipe pemukiman dan pola pajanannya. Metode- Studi potong lintang ini melibatkan masing-masing 20 orang dari penduduk sekitar TPU Bantar Gebang yang mewakili populasi kumuh dan civitas Fakultas Kedokteran Universitas Yarsi, Jakarta yang mewakili populasi nonkumuh. Nilai rasio albumin globulin diukur dengan cara membandingkan nilai albumin dengan selisih antara protein total dengan albumin. Komplemen C3 diukur menggunakan metode radial immunodiffusion. Hasil- Populasi kumuh memiliki nilai rasio albumin globulin lebih rendah signifikan dibanding populasi nonkumuh (p =0,004). 65% populasi kumuh memiliki ekspresi komplemen C3 tinggi (>1275,0) sedangkan 70% populasi nonkumuh memiliki ekspresi komplemen C3 rendah (≤1275,0) (p = 0,027). Rasio albumin globulin dan komplemen C3 memiliki tren korelasi negatif (R= −0,251, p = 0,062). Lima puluh persen populasi kumuh memiliki rasio albumin globulin rendah (≤1,38) dan ekspresi komplemen C3 tinggi (>1275,0) (p = 0,018). Kesimpulan- Terdapat perbedaan rerata rasio albumin globulin dan perbedaan proporsi ekspresi komplemen C3 yang signifikan pada populasi kumuh dan nonkumuh. Terdapat tren hubungan terbalik antara rasio albumin globulin dan ekspresi komplemen C3. Proporsi rasio albumin globulin rendah dan ekspresi komplemen C3 tinggi lebih banyak
Kata kunci: Albumin, Globulin, Rasio Albumin Globulin, Komplemen C3, C3, Kumuh, Nonkumuh


Introduction- Inhabitants of slum area have different pathogen exposure risk pattern compared to people living in high sanitary environment. Thus, different immune profile was expected. Albumin globulin ratio and complement C3, fraction of β-globulin functioned as central convergence point for complement activation pathways, were expected to be different among the population based on their environmental hygiene level. Methods- This cross-sectional study involves 20 participants each from inhabitants around Bantar Gebang Landfill and students from Medicine Faculty of Universitas Yarsi, Jakarta, represent slum population and nonslum population respectively. Albumin globulin ratio was obtained by comparing measured albumin with calculated globulin (total protein – albumin). Complement C3 serum concentration measured by radial immunodiffusion method. Results- Albumin globulin ratio was significantly lower in slum population compared to nonslum population (p = 0.004). High complement C3 serum concentration (>1275.0) was found in 65% slum population while 70% nonslum population have high complement C3 serum concentration (≤1275.0) (p = 0.027). This study shows a negative correlation tendency between albumin globulin ratio and complement C3, though not significant (R= −0.251, p = 0.062). Fifty percents of the slum population having a low albumin globulin ratio (≤1.38) and high complement C3 serum concentration (>1275.0) (p = 0.018). Conclusion- This study shows a significant different of albumin globulin ratio and complement C3 concentration serum among the slum population and nonslum population. Complement C3 was found negatively correlated with albumin globulin ratio, though not significant. Subjects having a low albumin globulin ratio and high complement C3 was found more in slum population.
Key words: Albumin, Globulin, Albumin Globulin Ratio, Complement C3, C3, Slum, Nonslum