Skripsi

Perbandingan Parameter Enzim Aminotransferase dan Cholinesterase pada Karsinoma Sel Hati akibat Infeksi Virus Hepatitis B dengan Virus Hepatitis C = Comparison of Aminotransferase Enzyme and Cholinesterase in Hepatocellular Carcinoma Caused by Hepatitis B Virus and Hepatitis C Virus Infection.

Karsinomal sel hati (KSH) merupakan jenis kanker hati terbanyak dengan etiologi tersering infeksi virus hepatitis B (VHB), diikuti infeksi virus hepatitis C (VHC) di urutan kedua. Penelitian ini bertujuan untuk membandingkan rerata kadar enzim aminotransferase, yang terdiri dari alanine aminotransferase (ALT), aspartate aminotransferase (AST) dan rasio AST/ALT, serta cholinesterase (CHE) pada pasien KSH akibat infeksi VHB dengan pasien KSH akibat infeksi VHC. Penelitian ini menggunakan desain studi potong-lintang dari data rekam medis pasien KSH di RSUPN Cipto Mangunkusumo periode 2013-2017. Jumlah data yang dianalisis secara bivariat untuk kadar ALT, AST, rasio AST/ALT, dan CHE pada pasien KSH dengan etiologi infeksi VHB adalah 122, 123, 121, dan 42 secara berurutan, serta jumlah data dengan etiologi infeksi VHC adalah 67, 68, 67, dan 20 secara berurutan. Uji normalitas Kolmogorov-Smirnov pada data kadar ALT, AST, rasio AST/ALT, dan CHE pasien KSH dengan etiologi VHB dan VHC menunjukkan persebaran yang tidak normal. Nilai median (minimum-maksimum) kadar ALT, AST, rasio AST/ALT, dan CHE adalah 46 U/L (6 U/L – 1331 U/L), 76 U/L (15 U/L – 1036 U/L), 1,63 (0,12 – 14,62), dan 3591,5 U/L (368 U/L – 12495 U/L) secara berurutan. Hasil uji Mann-Whitney untuk rerata kadar ALT, AST, rasio AST/ALT, dan CHE pada pasien KSH etiologi infeksi VHB dengan infeksi VHC adalah p = 0,199; 0,123; 0,711; 0,399 secara berurutan. Penelitian ini menyimpulkan bahwa tidak terdapat perbedaan bermakna rerata kadar aminotransferase (ALT, AST, dan rasio AST/ALT) dan CHE pada pasien KSH akibat infeksi VHB dengan infeksi VHC.
Kata kunci: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), rasio AST/ALT, Cholinesterase (CHE), Karsinoma Sel Hati (KSH).


Hepatocellular carcinoma (HCC) is the majority type of liver cancer, with the most frequent etiology is infection of hepatitis B virus (HBV) and followed by hepatitis C virus (HCV) in the second place. The aim of this study is to compare the level of aminotransferase enzyme, consists of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and AST/ALT ratio, and cholinesterase (CHE) enzyme in HCC with HBV infected patients to HCV infected patients. We conducted a cross-sectional study using medical record of HCC patients in Cipto Mangunkusumo Hospital by period of 2013 to 2017. The total data, that was bivariate analysed, for ALT, AST, AST/ALT ratio, and CHE level in HCC patients with HBV etiology were 122, 123, 121, and 42 respectively, while the total data for HCC patients with HCV etiology were 67, 68, 67, and 20 respectively. Kolmogorov-Smirnov normality test showed the level of ALT, AST, AST/ALT ratio, and CHE were not normally distributed. Median value (minimum – maximum) level of ALT, AST, AST/ALT ratio, and CHE were 46 U/L (6 U/L – 1331 U/L), 76 U/L (15 U/L – 1036 U/L), 1,63 (0,12 – 14,62), and 3591,5 U/L (368 U/L – 12495 U/L) respectively. Mann-Whitney test for the level of ALT, AST, AST/ALT ratio, and CHE in HCC with HBV infected patients to HCV infected patients were p = 0,199; 0,123; 0,711; 0,399 respectively. This study concludes that there is no significant difference between aminotransferase level (ALT, AST, AST/ALT ratio) and CHE level between HCC patients with HBV-infected etiology to HCC patients with HCV-infected etiology.
Key Words: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, cholinesterase (CHE), hepatocellular carcinoma