Tesis

Pengaruh Pajanan Extreme Low Frequency – Pulsed Electromagnetic Field dalam Proses Penyembuhan Fraktur Delayed Union Femur Tikus Sprague Dawley: Kajian Terhadap Skor Radiologi Rust dan Failure Load dari Pemberian Gaya Aksial = The Effect of Extreme Low Frequency - Pulsed Electromagnetic Field Exposure in the Healing Process of Sprague Dawley Mouse Delayed Union Femur Fracture: Study of Rust Radiology Score and Failure Load of Axial Force.

Latar Belakang: Fraktur adalah salah satu penyakit yang menjadi permasalahan yang cukup besar dalam bidang kesehatan di dunia, terutama di negara berkembang. Secara umum fraktur dapat sembuh dengan normal. Pada beberapa kondisi, penyembuhan fraktur tidak terjadi secara normal, namun mengalami komplikasi seperti delayed union atau non union. Penyembuhan fraktur yang sukses merupakan suatu interaksi yang kompleks antara proses angiogenesis dan osteogenesis (interaksi osteoblas-osteoklas). Stimulus fisika berupa pajanan PEMF (pulsed electromagnetic fields) menunjukkan pengaruh proses osteogenesis baik dalam tahap perkembangan penulangan embrio dan tahap penyembuhan fraktur. Tujuan: Penelitian ini bertujuan untuk mengetahui penyembuhan fraktur tulang delayed union pada hewan coba pada pemberian ELF-PEMF dengan melihat skor radiologi RUST dan Failure Load dari Pemberian Gaya Aksial. Metode: Penelitian dilakukan uji eksperimental 56 hewan coba di Laboratorium Hewan Departemen Gizi, Fakultas Kedokteran Universitas Indonesia. Penelitian dilakukan dengan membandingkan nilai RUST Score dan Load Score pada kedua kelompok hewan coba. Hasil: Penelitian dilakukan selama Agustus-September 2018 dengan 56 hewan coba. Tidak ada perbedaan karakteristik hewan coba pada penelitian. Didapati bahwa terdapat perbedaan bermakna Rust Score pada kelompok perlakuan dan kelompok kontrol pada setiap minggu pemeriksaan dan terdapat perbedaan bermakna Load Score pada minggu keempat dan kelima. Kesimpulan: Penelitian ini menyimpulkan terdapat perbaikan penyembuhan fraktur delayed union pasca pemberian ELF-PEMF dilihat dari perbedaan nilai Rust score dan load score.
Kata kunci: Extreme Low Frequency – Pulsed Electromagnetic Field, fraktur delayed union, Rust score, Load score


Background: Fracture is a major health problem in the world, especially in developing countries. Usually, fractures can heal normally. In some conditions, the healing process do not occur normally, but become delayed union or non union as a complication. Successful healing of fractures is a complex interaction between the process of angiogenesis and osteogenesis (the interaction of osteoblasts and osteoclast). Physical stimuli such as exposure of PEMF (pulsed electromagnetic fields) influences of the osteogenesis process both in the development stage of embryo reinforcement and the fracture healing stage. Objective: The aim of this study is to determine the healing of delayed union fractures in experimental animals due to the expossure of ELF-PEMF. The healing process determined by RUST scores and Failure Load scores. Methods:The experimental study was conducted Department of Nutrition Animal Laboratory, Faculty of Medicine, Universitas Indonesia with 56 experimental rats. The study was conducted by comparing the RUST Score and Load Score values in the two experimental animal groups. Result: The study was conducted during August-September 2018 with 56 experimental animals. There were no difference of animal characteristics in the study. It was found that there were significant differences in Rust Score in the treatment and control groups in each examination week and there were significant differences in Load Score in the fourth and fifth weeks Conclusion: This study concluded that there was an improvement in delayed union fracture healing after the administration of ELF-PEMF as seen from the difference in Rust score and load score.
Keywords: Extreme Low Frequency – Pulsed Electromagnetic Field, delayed union fracture, Rust score, Load score