Tesis

Korelasi Interleukin-6 dengan E-Selectin sebagai Penanda Disfungsi Endotel pada Pasien Artritis Reumatoid tanpa Faktor Risiko Tradisional Kardiovaskular = Correlation between Interleukin-6 and E-Selectin as a Marker of Endothelial Dysfunction in Rheumatoid Arthritis Patient Without Traditional Cardiovascular Risk Factor.

Latar Belakang: Kejadian kardiovaskular merupakan salah satu manifestasi ekstra artikular yang sering ditemukan pada pasien Artritis Reumatoid (AR). Mediator inflamasi aterogenik pada AR seperti interleukin-6 (IL-6) diduga menjadi salah satu faktor risiko nontradisional kardiovaskular yang berkontribusi meningkatkan penanda disfungsi endotel seperti E-Selectin. Belum ada studi yang menilai korelasi IL-6 dengan E-Selectin pada pasien AR tanpa faktor risiko tradisional kardiovaskular. Tujuan: Mengetahui peran mediator inflamasi dalam kejadian disfungsi endotel, khususnya korelasi IL-6 dan E-Selectin, pada pasien artritis reumatoid tanpa faktor risiko kardiovaskular. Metode: Studi potong-lintang dilakukan pada 40 pasien AR di Poliklinik Reumatologi RSUPN Dr. Cipto Mangunkusumo, Indonesia, pada bulan September-November 2017. Pemeriksaan IL-6 dan E-Selectin dilakukan dengan teknik enzyme-linked immunosorbent assay (ELISA). Analisis korelasi bivariat dilakukan untuk menemukan korelasi kedua penanda tersebut. Hasil: Rerata usia subjek penelitian ini adalah 44,9 (13,1) tahun dan median durasi sakit adalah 36 bulan. Korelasi kadar IL-6 dengan kadar E-Selectin memiliki kekuatan korelasi lemah tetapi tidak bermakna secara statistik (r = 0.232, p=0,149). Kesimpulan: Tidak terdapat korelasi antara IL-6 dengan E-Selectin pada pasien AR tanpa faktor risiko tradisional kardiovaskular.
Kata Kunci: artritis reumatoid, E-Selectin, interleukin-6, kejadian kardiovaskular mediator inflamasi,


Background Cardiovascular event is one of the most common extra articular manifestation in Rheumatoid Arthritis (RA) patients. Atherogenic inflammatory mediator in RA including interleukin-6 (IL-6) was thought to be one of nontraditional cardiovascular risk factor contributing to increase the endothelial dysfunction biomarker such as E-Selectin. There was still no study determining the correlation between IL-6 and E-Selectin in RA without traditional cardiovascular risk factor. Objective: To determine the correlation between inflammatory mediator and endothelial dysfunction event, especially between IL-6 and E-Selectin, in RA patient without traditional cardiovascular risk factor. Method: A cross-sectional study was performed to 40 RA patients of Rheumatology Clinic of Cipto Mangunkusumo National General Hospital, Indonesia from September to November 2017. Measurement of the level of IL-6 and E-Selectin were performed using enzyme-linked immunosorbent assay (ELISA). Bivariate correlation analysis was performed to determine the correlation between those two biomarkers. Result: The mean age of this study subjects was 44.9 (13.1) years and median of disease duration was 36 month. This study showed showed weak correlation between IL-6 and E-Selectin level, but not statistically significant.232, p=0.149). Conclusion: There is no correlation between IL-6 and sE-Selectin in rheumatoid arthritis patient without traditional risk factor cardiovascular
Keywords: traditional risk factor cardiovascular, E-Selectin, interleukin-6, pro inflammatory mediator, rheumatoid arthritis