Tesis

Hubungan Kadar Imunoglobulin E Total Serum dengan Derajat Keparahan Pasien Dewasa Asma Alergik = Relationship Between Total Immunoglobulin E Serum Level And Severity of Allergic Asthma in Adults.

Latar Belakang: Asma alergik merupakan penyakit inflamasi jalan napas kronik yang diperantarai oleh mekanisme imunologik. IgE berperan penting dalam memediasi respons alergik pada asma, namun belum ada studi tentang kadar IgE total pada pasien dewasa asma di Indonesia berdasarkan derajat keparahannya. Tujuan: Mengetahui hubungan kadar Ig E total serum dengan derajat keparahan pasien dewasa asma alergik. Metode: Desain penelitian potong lintang dan merupakan bagian dari penelitian utama pada pasien yang berobat di Poliklinik Alergi dan Imunologi, Departemen Ilmu Penyakit Dalam, RS Cipto Mangunkusumo, Jakarta. Derajat keparahan asma ditentukan berdasarkan kriteria National Institutes of Health (NIH) 2007 dan dibagi menjadi intermiten dan persisten. Pemeriksaan IgE total serum menggunakan ELISA (Polycheck Allergy, Biocheck GmbH, Munster, Jerman). Perbedaan median dianalisis dengan uji Mann-Whitney. Hasil: Sebanyak 60 subyek dilibatkan dalam penelitian ini. Berdasarkan derajat keparahannya, 11 pasien (18,3%) mengalami asma intermiten dan 49 pasien (81,67%) mengalami asma persisten. Rerata (simpang baku) kadar IgE total serum pada seluruh subyek adalah 42,35 (32,7) IU/mL. Median kadar serum IgE total pada asma persisten lebih tinggi secara signifikan dibandingkan dengan asma intermiten (37 vs. 16 IU/mL; p = 0,004). Kesimpulan: Terdapat hubungan antara kadar IgE total serum dengan derajat keparahan pasien dewasa asma alergik. Rerata kadar IgE total serum pada pasien asma alergik persisten lebih tinggi secara bermakna dibandingkan dengan pasien asma alergik intermiten.
Kata Kunci: asma alergik, derajat keparahan asma, kadar IgE total serum .


Introduction : Allergic asthma is a chronic inflammatory airway disease mediated by immunologic mechanism. IgE plays an important role in mediating allergic response in asthma; however, there was no study on total IgE levels in adult asthmatic patients in Indonesia based on disease severity. Objective : To determine whether there was a relationship between total IgE serum level and severity of allergic asthma in adults. Methods : This was a cross-sectional study on adult allergic asthma. This study was a part of a larger study within the outpatient clinic of Allergy and Immunology, Cipto Mangunkusumo Hospital, Jakarta. Asthma severity was defined based on National Institutes of Health (NIH) 2007 criteria and were grouped as intermittent or persistent. Serum total IgE testing was done on blood serum using ELISA (Polycheck Allergy, Biocheck GmbH, Munster, Germany). Difference between two groups were analyzed using Mann-Whitney. Results: There were 60 patients included in this study. Based on the degree of severity, 11 patients (18.3%) had intermittent asthma and 49 patients (81.67%) had persistent asthma. The mean (standard deviation) total serum IgE level in all subjects was 42.35 (32.7) IU/ mL. Median total serum IgE level was significantly higher in persistent asthma than intermittent asthma (37 vs. 16 IU/mL; p = 0.004). Conclusion : There was a relationship between total IgE serum level and severity of allergic asthma in adults. Mean serum total IgE levels in persistent allergic asthma patients were significantly higher than in patients with intermittent allergic asthma.
Keywords : allergic asthma, asthma severity, total IgE