Skripsi

Perbandingan Efektivitas Metode Dekontaminasi N-acetyl- L-cysteine-sodium hydroxide(NALC-NaOH) dan Modified Petroff terhadap Kultur Mycobacterium tuberculosis = Comparison of Effectivity between N-acetyl-L-cysteine- sodium hydroxide (NALC-NaOH) and Modified Petroff Decontamination Method in Mycobacterium tuberculosis Culture.

N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH) dan Modified Petroff merupakan dua metode dekontaminasi yang cukup sering digunakan untuk kultur TB. Pada penelitian berdesain cross sectional ini, dilakukan perbandingan proporsi kultur terkontaminasi dan hasil kultur positif antara kelompok sampel yang diproses dengan NALC-NaOH dan Modified Petroff. Analisis bivariat menunjukan bahwa proporsi kultur terkontaminasi pada sampel yang diproses dengan teknik NALC-NaOH (38,2%) secara signifikan (p=0,034) lebih tinggi dibanding dengan teknik Modified Petroff (18,2%). Akan tetapi, tidak terdapat perbedaan yang signifikan (p=1,000) antara proporsi hasil kultur positif pada kelompok sampel yang diproses dengan teknik NALC-NaOH (73,5%) dan Modified Petroff (73,3%). Hasil yang diperoleh pada penelitian ini berbeda dengan hasil penelitian yang sebelumnya telah membandingkan antara teknik NALC-NaOH dan Modified Petroff.
Kata kunci: Mycobacterium tuberculosis, tuberkulosis(TB), dekontaminasi, N- acetyl-L-cysteine-sodium hydroxide(NALC-NaOH), Modified Petroff


N-acetyl-L-cysteine-sodium hydroxide (NALC-NaOH) and Modified Petroff are two decontamination methods that are widely used for TB culture. This crosssectional study compares the proportion of contaminated culture and positive culture result between samples treated with NALC-NaOH and Modified Petroff. Bivariate analysis of the data showed that the proportion of contaminated culture was significantly (p=0,034) higher in samples treated with NALC-NaOH (38,2%) than in those treated with Modified Petroff (18,2%). However, significant difference in the proportion of positive culture result between samples treated with NALC-NaOH (73,5%) and Modified Petroff (73,3%) was not shown (p=1,000). The result of this study differs from that of previous study that compared NALCNaOH dan Modified Petroff.
Keywords: Mycobacterium tuberculosis, tuberculosis (TB), decontamination, Nacetyl-L-cysteine-sodium hydroxide(NALC-NaOH), Modified Petroff