Tesis

Efek Kombinasi Tetes Mata Hydroxypropyl-guar terhadap Perubahan Stabilitas Lapisan Air Mata pada Mata Kering Terkait Sindrom Sjögren = Effect of Combination Therapy of Sodium Hyaluronate and Hydroxypropyl-guar in Tear Film Stability in Patients with Sjögren Syndrome Associated Dry Eye.

Tesis ini bertujuan untuk menilai stabilitas LAM mata kering terkait sindrom Sjögren (SS) yang diberikan terapi kombinasi tetes mata sodium hialuronat 0,1% (SH) dan hydroxypropyl (HP)-guar, atau monoterapi tetes mata sodium hialuronat (SH). Sebanyak 17 pasien SS dalam penelitian ini dibagi ke dalam 2 kelompok. Kelompok pertama mendapatkan kombinasi SH dan HP-guar sementara kelompok kedua mendapatkan terapi SH. NIKBUT, Schirmer, skor pewarnaan okular dan sitologi impresi, serta keluhan subjektif yang dilakukan sebelum dan sesudah pemberian obat. Setelah terapi selama 28 hari, terdapat peningkatan median NIKBUT, Schirmer, skor pewarnaan okular, densitas sel Goblet dan keluhan subjektif pada mata kering terkait SS.
Kata kunci Mata kering, sindrom Sjögren, sodium hialuronat, hydroxypropyl (HP)-guar, NIKBUT


The objectives of the study is to assess the stability of dry eye LAM associated with Sjögren syndrome (SS) given combination therapy of sodium hyaluronate 0.1% (SH) and hydroxypropyl (HP) -guar, or monotherapy sodium hyaluronic (SH). A total of 17 SS patients in this study were divided into 2 groups. The first group received a combination of SH and HP-guar while the second group received SH therapy. NIKBUT, Schirmer, ocular staining score and impression cytology, as well as subjective complaints made before and after drug administration. After 28 days of therapy, there was a median increase in NIKBUT, Schirmer, ocular staining scores, Goblet cell density and subjective complaints on SS-related dry eyes.
Keywords: dry eye, Sjögren syndrome, hydroxypropyl (HP)-guar, NIKBUT, Schirmer, ocular staining score, Goblet cell density