Tesis

Korelasi antara Asupan Seng dan Kadar Seng Serum dengn Kadar C-reactive protein pada Pasien Kanker Kepala dan Leher = Correlation between Zinc Intake and Zinc Serum Levels with C-reactive Protein Level in Head and Neck Cancer Patients.

Proses inflamasi pada kanker kepala leher menyebabkan peningkatan produksi sitokin proinflamasi dan sintesis protein fase akut (c-reactive protein, CRP) yang kemudian menyebabkan perubahan metabolisme dan anoreksia pada penderitanya. Seng merupakan zat gizi yang memiliki peran penting dalam menekan inflamasi, namun dilaporkan sekitar 65% pasien kanker kepala leher mengalami kekurangan seng. Penelitian potong lintang ini bertujuan mengetahui korelasi antara asupan seng dan kadar seng serum dengan kadar CRP sebagai upaya menekan inflamasi sehingga dapat mengurangi morbiditas dan mortalitas pasien kanker kepala leher. Dari 49 subjek yang dikumpulkan di Poliklinik Onkologi RS Kanker Dharmais Jakarta, 67,3% adalah laki-laki, 53,1% berada pada rentang usia 46–65 tahun, 65,3% adalah kanker nasofaring dan 69,4% berada pada stadium IV. Seluruh (100%) subyek memiliki asupan seng dibawah nilai angka kecukupan gizi. Rerata kadar seng serum subjek adalah 9,83±2,62 µmol/L. Terdapat korelasi negatif yang lemah antara kadar seng dengan kadar CRP subjek (r =-0,292, p =0,042), namun tidak terdapat korelasi antara asupan seng dengan kadar CRP subjek (p =0,86).
Kata kunci : asupan seng; kadar c-reactive protein; kanker kepala dan leher; kadar seng serum.


The inflammatory process of head and neck cancer leads to increase the production of proinflammatory cytokines and the synthesis of c-reactive protein (CRP), which then causes metabolic alteration and anorexia in the patients. Zinc is one of nutrient that has an important role in suppressing inflammation. It is reported that about 65% of head and neck cancer patients have zinc deficiency. The aim of this cross sectional study is to determine the correlation between zinc intake and serum zinc levels with CRP level as an effort to reduce inflammation to reduce the morbidity and mortality of head and neck cancer patients. Subjects were obtained in the Oncology Polyclinic Dharmais Cancer Hospital. From 49 subjects 67,3% were male, 53,1% subjects were in the age range between 46–65 years, 65,3% is nasopharyngeal cancer and 69,4% were already in stage IV. All subjects (100%) have a zinc intake below the recommendation dietary allowance. The mean serum zinc concentration of the subjects was 9.83±2.62 μmol/L. There was a weak significant negative correlation between zinc concentration and CRP levels of subjects (r =-0.292, p =0.042), but there was no correlation between zinc intake and CRP levels of subjects (p =0.86).
Keywords: c-reactive protein levels; head and neck cancer; zinc intake; zinc serum levels