Tesis

Pengaruh Pemberian Ekstrak Ophiocephalus striatus terhadap Kadar IGF-1 dan Albumin Pasien Usia Lanjut dengan Malnutrisi = The Effect of Ophiocephalus striatus Extract on Levels of IGF-1 and Albumin in Elderly Malnourished Patients.

Latar Belakang.Ophiocephalus striatus berpotensi meningkatkan kadar IGF-1 dan albumin karena mengandung asam amino, asam lemak, vitamin, dan mineral. Belum ada penelitian menggunakan ekstrak Ophiocephalus striatus khusus pada pasien usia lanjut dengan malnutrisi. Tujuan. Mengetahui pengaruh pemberian ekstrak Ophiocephalus striatus terhadap kadar IGF-1 dan albumin pasien usia lanjut dengan malnutrisi Metode. Uji klinis acak tersamar ganda dilakukan pada pasien rawat inap yang telah melewati kondisi akut dan dibolehkan pulang, berusia ≥ 60 tahun dengan skor Mini Nutritional Assessment ≤ 23,5 dan kadar albumin < 3,5 g/dL. Dilakukan randomisasi untuk mendapatkan ekstrak Ophiocephalus striatus 10 gram sehari atau plasebo selama 14 hari. Kadar IGF-1 dan albumin diperiksa sebelum dan sesudah perlakuan. Pengaruh pemberian ekstrak OS dianalisis menggunakan uji t tidak berpasangan atau uji Mann-Whitney. Hasil. Randomisasi dilakukan terhadap 109 subjek, sebanyak 90 subjek menyelesaikan penelitian hingga 14 hari (masing-masing kelompok45 orang). Median usia 69 (64;75) tahun dengan perbandingan laki-laki dan perempuan 2 : 3. Didapatkan perubahan kadar IGF-1 dan albumin sesudah perlakuan pada kelompok ekstrak OS vs plaseboberturut-turut 14,70 (0,30;31,50) ng/mL vs 1,00 (-6;13,15) ng/mL (p = 0,002) dan 0,50 (0,15;0,70) g/dL vs 0,10 (0,0;0,50) g/dL(p = 0,003). Simpulan. Ekstrak Ophiocephalus striatus dapat meningkatkan kadar IGF-1 dan albumin pasien usia lanjut dengan malnutrisi
Kata kunci.Ophiocephalus striatus, IGF-1, albumin, usia lanjut



Backgound.Supplementation with Ophiocephalus striatus is potential to increase IGF-1 and albumin levels in elderly malnourished patients beacause of the contents of amino acids, fatty acids, vitamins, and minerals. Objective.This study was conducted to confirm the effect of Ophiocephalus striatusextract on levels of IGF-1 and albumin in elderly malnourished patients. Method.The study design is a double-blind randomized controlledtrial involving hospitalizedmalnourished ≥ 60 years old patientsin acute ward before discharged, with Mini Nutritional Assessment score ≤ 23.5 and albumin level < 3.5 g/dL.A total of 109 subjects were randomly divided into two groups including one group received Ophiocephalus striatus extract 10 g per day and another group received plasebo for 14 days. Albumin and IGF-1 levelswere obtained before and after intervention. Results.Ninety subjects completed the study (extract group = 45 subjects; plasebo goup = 45 subjects) for 14 days. Median of age was 69 (64;75) years, with male to female ratio were 2 : 3. The delta differences of IGF-1 and albumin levels between extract group and placebo group were 14.7 (0.30;31.5) ng/mL vs 1.00 (6;13.15) ng/mL (p = 0.002) and 0.50 (0.15;0.70) g/dL vs 0.10 (0,0;0.50)g/dL (p = 0.003), respectively. There were significant differences between extract and placebo group. Conclusions. Supplementation with Ophiocephalus striatus extract was associated with a significant increase in IGF-1 and albumin levels.
Key words. Ophiocephalus striatus, IGF-1, albumin, elderly