Tesis

Efek Hibiscus sabdariffa Linn. terhadap kadar IL-1β dan IL-1ra pada plasma dan hipokampus tikus overtraining serta korelasinya dengan memori spasial = The effect of Hibiscus sabdariffa Linn. on IL-1β and IL-1ra levels in plasma and hippocampus of overtraining rats and its correlation with spatial memory.

Overtraining meningkatkan IL-1β sistemik akibat mikrotrauma otot sehinggga memengaruhi hipokampus yang penting dalam pembentukan konsolidasi memori spasial. Pemberian H. sabdariffa diharapkan menurunkan IL-1β dan meningkatkan IL-1ra sehingga berpotensi mencegah gangguan konsolidasi memori spasial. Penelitian ini menggunakan metode eksperimental terhadap 20 tikus Wistar jantan (Rattus norvegicus, 250-300 gram), terbagi ke dalam 4 kelompok yaitu kontrol (C), kontrol H. sabdarifa (C-Hib), latihan fisik overtraining (OT) dan latihan fisik overtraining yang diberi H. sabdarifa (OT-Hib). Pemberian ekstrak metanol H. sabdariffa 500 mg/kgBB berpotensi sebagai antiinflamasi melalui peningkatan sitokin antiinflamasi (IL-1ra) plasma darah secara bermakna sehingga mencegah gangguan fungsi konsolidasi memori spasial tikus overtraining.
Kata kunci: Overtraining, H. Sabdariffa, konsolidasi memori spasial, hipokampus, plasma, IL-1β, IL-1ra.


Overtraining lead to increase IL-1β systemically due to muscle mikrotrauma that affect hippocampus which was important in the formation of spatial memory consolidation. Administration H. Sabdariffa is expected to decrease IL-1β and increases IL-1ra thereby potentially preventing impairment of spatial memory consolidation. This research is an experimental study using 20 male Wistar rats (Rattus norvegicus, 250-300 g) were divided into 4 groups: control (C), H. sabdarifa control (C-Hib), physical exercise overtraining (OT) and physical exercise overtraining by H. sabdarifa (OT-Hib). Administration of the methanolic extract of H. Sabdariffa 500 mg / kg body weight was a potential anti-inflammatory by increase anti-inflammatory cytokines (IL-1ra) in blood plasma so that prevent the impairment of spatial memory consolidation in overtraining Wistar rat.
Keywords: Overtraining, H. Sabdariffa, spatial memory consolidation, the hippocampus, plasma, IL-1β, IL-1ra.