Tesis

Korelasi antara Kadar Likopen Serum dengan Fungsi Paru pada Penderita Penyakit Paru Obstruktif Kronik = Serum Lycopene Level and Its Correlation with Lung Function among Chronic Obstructive Pulmonary Disease Patients.

Penyakit Paru Obstruktif Kronik (PPOK) merupakan penyakit dengan penurunan fungsi paru, yang melibatkan stres oksidatif pada patogenesisnya. Likopen diketahui merupakan salah satu karotenoid utama pada jaringan paru dengan aktivitas antioksidan sangat kuat. Penelitian potong lintang ini dilakukan di RSUP Persahabatan, Jakarta Timur, melibatkan 47 subjek dengan tujuan mengetahui korelasi antara kadar likopen serum dengan fungsi paru pada penderita PPOK. Karakteristik subjek dan asupan likopen didapatkan melalui wawancara menggunakan food frequency questionairre (FFQ) semi-kuantitatif. Kategori diagnosis PPOK didapatkan dari rekam medis atau wawancara. Status gizi ditentukan berdasarkan Indeks Masa Tubuh (IMT), fungsi paru ditentukan menggunakan spirometri, dan kadar likopen serum diukur dengan High Performance Liquid Chromatography (HPLC). Semua subjek laki-laki, terbanyak berusia ≥60 tahun, hampir separuh bekas perokok berat, 51% berstatus gizi normal. Asupan likopen 4.407 (256–18.331) g/hari, lebih rendah daripada asupan orang sehat. Kadar likopen serum 0,57± 0,25 mol/L, setara dengan orang sehat. Terdapat korelasi positif (p=0,001; r=0,464) antara kadar likopen serum dengan VEP 1 /KVP, namun tidak terdapat korelasi kadar likopen serum dengan VEP 1 /Prediksi dan KVP/Prediksi.
Kata kunci: PPOK, fungsi paru, likopen, Indonesia


Chronic Obstructive Pulmonary Disease (COPD) is a disease with decreasing pulmonary function, involving oxidative stres on its pathogenesis. Lycopene is one of the main carotenoids in lungs, with very potent antioxidant property. This crosssectional study was conducted at Persahabatan Hospital Jakarta, involving 47 subjects, aiming to investigate the correlation between serum lycopene level and lung function in COPD subjects. Interview was used to assess subjects’ characteristics and lycopene intake using semi-quantitative food frequency questionnaire (FFQ). COPD grouping was gathered from medical records or interview. Body mass index (BMI) was used to determine nutritional status, lung function test conducted by spirometry, while lycopene serum level was assessed using High Performance Liquid Chromatography (HPLC) method. All subjects were male, majority ≥60 years old, almost half ex-heavy smokers, about 51% were in normal nutritional status. Lycopene intake was 4,407 (256–18,331)g/day, lower compared to healthy subjects’. Serum lycopene level was 0.57±0.25mol/L, similar to normal level in healthy individuals. There was a correlation (p=0.001;r=0.464) between serum lycopene level and FEV 1 /FVC, but no correlations between serum lycopene level and FEV 1 %, neither was FVC%.
Keywords : COPD, lung function, lycopene, Indonesia