Tesis

Kadar Hypoxia Inducible Factor-1α (HIF-1α) dan Intercellular Adhesive Molecule-1 (ICAM-1) Pasca Bevacizumab Intravitreal pada Retinopati Diabetik Proliferatif.

Tesis ini bertujuan untuk menilai kadar Hypoxia-inducible Factor-1α (HIF-1α) dan Intercellular Adhesion Molecule-1 (ICAM-1) vitreus yang diketahui berperan dalam progresivitas retinopati diabetik proliferatif. Pemeriksaan dengan metode enzyme-linked immunosorbent assay (ELISA) dilakukan pada kelompok kontrol (langsung dilakukan vitrektomi) dan kelompok yang mendapat bevacizumab intravitreal (BIV) 1-2 minggu previtrektomi. Hubungan kedua protein tersebut terhadap ketebalan makula sentral previtrektomi juga turut dinilai. Kadar HIF-1α and ICAM-1 vitreus didapatkan tidak berbeda bermakna antara kedua kelompok, namun nilai median menunjukkan kadar yang lebih tinggi pada kelompok BIV. Tidak didapatkan hubungan korelasi yang bermakna antara kadar kedua protein tersebut terhadap ketebalan makula sentral previtrektomi.
Keywords : retinopati diabetik proliferatif, bevacizumab, HIF-1α, ICAM-1


This study assessed the levels of Hypoxia-inducible Factor-1α (HIF-1α) and Intercellular Adhesion Molecule-1 (ICAM-1) which were known to play a role in the proliferative diabetic retinopathy progressivity. Measurement by enzyme- linked immunosorbent assay (ELISA) were carried out in vitreous of the control group (without intravitreal bevacizumab) and the intravitreal bevacizumab (IVB) group that received IVB 1-2 weeks prior to vitrectomy. Correlation between HIF1α and ICAM-1 with central macular thickness were also studied. The levels of HIF-1α and ICAM-1 did not differ significantly between the groups, but the median values indicate higher levels in the IVB group. There were no significant correlation between the levels of HIF-1α and ICAM-1 to the central macular thickness.
Keywords : proliferative diabetic retinopathy, bevacizumab, HIF-1α, ICAM-1