Tesis

Korelasi Nilai T2* Pankreas dengan Kadar Glukosa Darah pada Subyek Thalassemia Anak dan Dewasa = Correlation Between Pancreatic T2* Values Against Blood Glucose Levels in Thalassemic Children and Adults.

Latar Belakang dan tujuan: Pemeriksaan MRI T2* pankreas merupakan pemeriksaan yang lebih akurat dalam menilai hemosiderosis pankreas, namun memiliki keterbatasan karena hanya tersedia di kota-kota besar. Penelitian ini bertujuan untuk mengetahui korelasi nilai T2* pankreas dengan kadar glukosa darah, karakteristik T2* pankreas dan kadar glukosa darah subyek penelitian, serta pengaruh letak ROI terhadap nilai T2* pankreas. Metode: Penelitian menggunakan desain potong lintang pada 52 subyek anak dan 12 subyek dewasa antara September 2015-Juni 2016. Hasil: Nilai T2* pankreas anak 2,71-48,77 ms dan dewasa 6,49-41,82 ms. Kadar glukosa darah puasa anak rerata 87,31 ± 11,01 mg/dL dan dewasa 88,00 ± 10,27 mg/dL. Korelasi nilai T2* pankreas terhadap kadar glukosa darah puasa anak r=0,198 (p=0,160) dan dewasa r=0,004 (p=0,991). Hubungan nilai T2* pankreas dengan letak ROI didapatkan p=0,105. Kesimpulan: Tidak terdapat korelasi nilai T2* pankreas dengan kadar glukosa darah puasa pada anak dan dewasa. Tidak terdapat perbedaan signifikan nilai T2* pankreas menurut letak ROI.
Kata kunci: T2*pankreas, glukosa darah, ROI (regio of interest)


Background and Objective: T2 * MRI examination is more accurate in assessing pancreatic hemosiderosis but lack of availability to be used routinely. This study determined the correlation value of T2 * pancreas with blood glucose levels, the characteristics of T2 * pancreas and blood glucose levels, and the effect of ROI location to the value of T2 * pancreas. Methods: Cross sectional study held in September 2015-June 2016, involving 52 children and 12 adults. Results: Pancreatic T2 * values of children are 2.71 to 48.77 ms and adults are 6.49 to 41.82 ms. Mean of fasting blood glucose levels in children are 87.31 ± 11.01 mg / dL and adults are 88.00 ± 10.27 mg / dL. Correlation (r) between value of pancreatic T2 * against children’s fasting blood glucose levels was 0.198 (p = 0.160) and adults was 0.004 (p = 0.991). Significancy value (p) of relationship between pancreatic T2 * and ROI of pancreas was 0.105. Conclusion: There was no significant correlation between pancreatic T2 * values with fasting blood glucose levels in children and adults, nor significant difference in T2 * values according to ROI of pancreas.
Keywords: T2 * pancreas, blood glucose, ROI (region of interest)