Skripsi

Five Years of Surveillance Study of Extended Spectrum Beta Lactamase Producing Klebsiella pneumonia Isolated from Various Specimens at Several Health Services in Jakarta = Studi Selama Lima Tahun Terhadap Isolat Klebsiella pneumoniae penghasil Extended Spectrum Beta Lactamase (ESBL) dari Berbagai Spesimen pada Beberapa Pusat Pelayanan Kesehatan di Jakarta.

Background: Extended Spectrum Beta Lactamase (ESBL) is one of beta- lactamases group that hydrolyzes third generation cephalosporin, penicillin, and aztreonam. This event might cause failure in treating the patients infected with Klebsiella pneumoniae due to resistance problem. In Indonesia, there is still inadequate data regarding ESBL-producing K. pneumoniae. Method: Samples were obtained from all Klebsiella pneumoniae isolates data from WHO.net in Microbiology Department, Faculty of Medicine, Universitas Indonesia from 2009 to 2014. Therafter, data was analyzed and compared year by year using chi-square test, SPSS version 16. Results: The total of K. pneumoniae in 2009-2014 was 555 isolates. There was a marked decrease (p0.05) from 2010 to 2011 (17.4% to 9.4%). Unfortunately, it then increased from 2011 until 2014 (9.4%, 10%, 10.2%, 12.1% respectively), although it was insignificant (p>0.05). Moreover, if we compare the prevalence of ESBL-producing K. pneumoniae in 2009 and 2014, we found a significant decreased prevalence (p