Tesis

The Safety Use of One-Per-Mil Tumescent Infiltration Into Skin Flap That Has Survived From the Preceding Ischemic Insult = Aplikasi Injeksi Tumescent ONEPERMIL pada Flap Kulit Hidup yang Sebelumnya Pernah Cedera Iskhemia.

Background: To observe the effect of One-per-mil tumescent injection on viable skin flaps that previously had suffered from an ischemic insult, so as to ascertain One-per-mil tumescent safety application in the related theme. Methods: 40 groin flaps from 20 healthy Wistar strained-Rattus novergicus weighing 220-270 grams were conditioned to acute ischemia by clamping the pedicle for 15 minutes. Merely totally survived and viable flaps on the seventh postoperative day were randomly divided into: One-per-mil tumescent infiltration group(A), normal saline infiltration group(B), and control group(C). Before and after the infiltration, transcutaneous oxygen tension (TcPO2) measurement was performed, and the changes values were calculated by statistical analysis using ANOVA and Paired T-Test. Viability of flaps was assessed clinically and by using Analyzing Digital Images® 7 days later. Results: TcPO2 readings yielded a decreasing value significantly (p